Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, 74 Zhongshan Rd 2, Guangzhou, 510080, People's Republic of China.
Guangdong Engineering Technology Research Center of Nutrition Translation, Guangzhou, 510080, People's Republic of China.
BMC Psychiatry. 2021 Nov 9;21(1):552. doi: 10.1186/s12888-021-03576-6.
Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style.
This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis.
In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13-5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11-5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father's parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms.
Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.
遗传因素可能与环境应激因素相互作用，导致抑郁症状的风险增加。本研究旨在探讨 FKBP5 多态性和 DNA 甲基化与中国青少年抑郁症状的关系，同时考虑到父母教养方式的作用。
本研究采用基于队列研究的巢式病例对照研究设计，病例组（n=120）和对照组（n=118）按年龄匹配。测量抑郁症状、父母教养方式和其他人口统计学特征。选择 FKBP5 基因中的 14 个潜在多态性和一个启动子区域进行基因分型和甲基化分析。
在调整后的模型中，FKBP5 rs7757037 与抑郁症状在共显性模型（AG 与 GG；调整后的优势比[OR] = 2.56，95%置信区间[CI] = 1.13-5.78）和显性模型（AA+AG 与 GG；OR = 2.38，95% CI = 1.11-5.120）中存在显著关联；rs2817032 和 rs2817035 多态性在共显性模型和显性模型中与抑郁症状相关。在共显性模型（P = 0.043）和显性模型（P = 0.043）中，rs7757037 与父亲教养方式之间存在显著的交互作用，但在进行多次检验校正后，基因-环境相互作用并不显著。此外，FKBP5 甲基化状态对抑郁症状的显著主效应未被观察到，FKBP5 甲基化状态与教养方式对抑郁症状的交互作用也不显著。
需要进一步的研究来确认 FKBP5 多态性和甲基化及其与父母教养方式的相互作用在更大样本中的作用。
