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非洲爪蟾核糖体基因启动子含有一个核因子-1结合位点。

The Xenopus laevis ribosomal gene promoter contains a binding site for nuclear factor-1.

作者信息

Walker P, Reeder R H

机构信息

Basic Sciences Division, Hutchinson Cancer Research Center, Seattle, WA 98102.

出版信息

Nucleic Acids Res. 1988 Nov 25;16(22):10657-68. doi: 10.1093/nar/16.22.10657.

DOI:10.1093/nar/16.22.10657
PMID:3205719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC338931/
Abstract

Nuclear Factor I (NF1) is a DNA binding protein that is known to function in the replication of Adeno virus and also binds to many promoters recognized by RNA polymerase II. We have found that there is also an NF1 binding site within the ribosomal gene promoter from Xenopus laevis as well as in several other promoters recognized by RNA polymerase I. The function of a binding site for a polymerase II transcription factor within a promoter recognized by polymerase I is not known. However, its presence suggests interesting regulatory possibilities.

摘要

核因子I（NF1）是一种DNA结合蛋白，已知其在腺病毒复制中发挥作用，并且还能与许多RNA聚合酶II识别的启动子结合。我们发现，非洲爪蟾核糖体基因启动子内以及RNA聚合酶I识别的其他几个启动子中也存在NF1结合位点。RNA聚合酶I识别的启动子内的RNA聚合酶II转录因子结合位点的功能尚不清楚。然而，它的存在暗示了有趣的调控可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/8ccc0c818525/nar00164-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/b9f28297e1ef/nar00164-0255-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/10a248343032/nar00164-0256-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/8de97fe55250/nar00164-0257-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/c3f9bd5068a5/nar00164-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/df640f637035/nar00164-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/8ccc0c818525/nar00164-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/b9f28297e1ef/nar00164-0255-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/10a248343032/nar00164-0256-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/8de97fe55250/nar00164-0257-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/c3f9bd5068a5/nar00164-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/df640f637035/nar00164-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54d/338931/8ccc0c818525/nar00164-0261-a.jpg

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1
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引用本文的文献

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Mol Cell Biol. 1990 Jun;10(6):2793-800. doi: 10.1128/mcb.10.6.2793-2800.1990.
2
Point mutation analysis of the Xenopus laevis RNA polymerase I core promoter.非洲爪蟾RNA聚合酶I核心启动子的点突变分析
Nucleic Acids Res. 1990 Jan 11;18(1):105-9. doi: 10.1093/nar/18.1.105.
3
Complex formation of nuclear proteins with the RNA polymerase I promoter and repeated elements in the external transcribed spacer of Cucumis sativus ribosomal DNA.

本文引用的文献

1
The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA.TGGCA结合蛋白：一种识别双链线性DNA上对称序列的真核细胞核蛋白。
Nucleic Acids Res. 1984 May 25;12(10):4295-311. doi: 10.1093/nar/12.10.4295.
2
Conserved arrangements of repeated DNA sequences in nontranscribed spacers of ciliate ribosomal RNA genes: evidence for molecular coevolution.纤毛虫核糖体RNA基因非转录间隔区重复DNA序列的保守排列：分子共同进化的证据
Nucleic Acids Res. 1985 Apr 11;13(7):2661-80. doi: 10.1093/nar/13.7.2661.
3
Footprinting of ribosomal RNA genes by transcription initiation factor and RNA polymerase I.
黄瓜核糖体DNA外部转录间隔区中核蛋白与RNA聚合酶I启动子及重复元件的复合物形成
Nucleic Acids Res. 1992 Jul 25;20(14):3685-91. doi: 10.1093/nar/20.14.3685.
利用转录起始因子和RNA聚合酶I对核糖体RNA基因进行足迹分析。
Proc Natl Acad Sci U S A. 1985 Dec;82(23):8004-8. doi: 10.1073/pnas.82.23.8004.
4
Ribosomal RNA transcription: proteins and DNA sequences involved in preinitiation complex formation.核糖体RNA转录：参与起始前复合物形成的蛋白质和DNA序列
Proc Natl Acad Sci U S A. 1985 Mar;82(6):1668-72. doi: 10.1073/pnas.82.6.1668.
5
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element.嗜热四膜虫核糖体DNA复制的调控涉及启动子元件的顺式作用上游重复序列。
Cell. 1986 Oct 24;47(2):229-40. doi: 10.1016/0092-8674(86)90445-9.
6
The interplay of DNA-binding proteins on the promoter of the mouse albumin gene.DNA结合蛋白在小鼠白蛋白基因启动子上的相互作用。
Cell. 1987 Dec 24;51(6):963-73. doi: 10.1016/0092-8674(87)90583-6.
7
The c-myc gene encodes superimposed RNA polymerase II and III promoters.c-myc基因编码叠加的RNA聚合酶II和III启动子。
Cell. 1987 Dec 24;51(6):1001-8. doi: 10.1016/0092-8674(87)90586-1.
8
Linker scanner mutagenesis of the Xenopus laevis ribosomal gene promoter.非洲爪蟾核糖体基因启动子的接头扫描诱变
Nucleic Acids Res. 1987 Sep 25;15(18):7429-41. doi: 10.1093/nar/15.18.7429.
9
The in vitro transcription of the 7SK RNA gene by RNA polymerase III is dependent only on the presence of an upstream promoter.RNA聚合酶III对7SK RNA基因的体外转录仅取决于上游启动子的存在。
Cell. 1987 Oct 9;51(1):81-7. doi: 10.1016/0092-8674(87)90012-2.
10
A common octamer motif binding protein is involved in the transcription of U6 snRNA by RNA polymerase III and U2 snRNA by RNA polymerase II.一种常见的八聚体基序结合蛋白参与RNA聚合酶III对U6 snRNA的转录以及RNA聚合酶II对U2 snRNA的转录。
Cell. 1987 Oct 9;51(1):71-9. doi: 10.1016/0092-8674(87)90011-0.