Department of Neurology, University of Washington, Seattle, Washington.
Comprehensive Stroke Program, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
J Stroke Cerebrovasc Dis. 2020 Apr;29(4):104670. doi: 10.1016/j.jstrokecerebrovasdis.2020.104670. Epub 2020 Feb 10.
Elevated serum apolipoprotein B and the apolipoprotein B/A1 ratio have been associated with ischemic stroke and intracranial atherosclerotic disease. We sought to assess the relationship between serum levels of apolipoprotein B, apolipoprotein A1, and the apolipoprotein B/A1 ratio with ischemic stroke subtypes and large artery atherosclerosis location.
We evaluated serum apolipoprotein B and apolipoprotein A1 levels in consecutive, statin-naïve, adult ischemic stroke patients admitted to an academic medical center in southern India. We evaluated for differences in the mean serum levels of apolipoprotein B, apolipoprotein A1, and the apolipoprotein B/A1 ratio between patients with ischemic stroke attributed to intracranial atherosclerotic disease, extracranial atherosclerotic disease, small vessel disease, and cardioembolism. In secondary analysis, we assessed for differences in these serum apolipoproteins between patients with moderate-severe intracranial atherosclerotic disease and extracranial atherosclerotic disease, irrespective of ischemic stroke subtype.
Among the 156 ischemic stroke patients enrolled in this study, there were no significant differences in serum levels of apolipoprotein B, apolipoprotein A1, and the apolipoprotein B/A1 ratio between patients with distinct ischemic stroke subtypes. No significant differences were found in serum levels of apolipoprotein B, A1 and the apolipoprotein B/A1 ratio between patients with moderate-severe intracranial atherosclerotic disease and moderate-severe extracranial atherosclerotic disease.
Serum levels of apolipoprotein B and A1 did not differ between ischemic stroke subtypes. Additional studies are needed to validate our findings and to better understand the relationship between serum apolipoproteins and stroke.
血清载脂蛋白 B 升高和载脂蛋白 B/A1 比值与缺血性卒中和颅内动脉粥样硬化性疾病相关。我们旨在评估血清载脂蛋白 B、载脂蛋白 A1 水平与缺血性卒中和大动脉粥样硬化病变部位的关系。
我们评估了连续纳入的、未服用他汀类药物的印度南部一所学术医疗中心的成年缺血性卒中患者的血清载脂蛋白 B 和载脂蛋白 A1 水平。我们评估了颅内动脉粥样硬化性疾病、颅外动脉粥样硬化性疾病、小血管疾病和心源性栓塞引起的缺血性卒中患者之间载脂蛋白 B、载脂蛋白 A1 和载脂蛋白 B/A1 比值的平均血清水平的差异。在二次分析中，我们评估了中重度颅内动脉粥样硬化性疾病和颅外动脉粥样硬化性疾病患者之间这些血清载脂蛋白的差异，而不考虑缺血性卒中亚型。
在这项研究中纳入的 156 例缺血性卒中患者中，不同缺血性卒中亚型患者的血清载脂蛋白 B、载脂蛋白 A1 和载脂蛋白 B/A1 比值无显著差异。中重度颅内动脉粥样硬化性疾病和中重度颅外动脉粥样硬化性疾病患者的血清载脂蛋白 B、A1 和载脂蛋白 B/A1 比值无显著差异。
血清载脂蛋白 B 和 A1 水平在缺血性卒中亚型之间无差异。需要进一步的研究来验证我们的发现，并更好地了解血清载脂蛋白与卒中之间的关系。
