Department of Biology, University of Colorado Colorado Springs, Colorado Springs, CO, 80918, United States.
Department of Molecular Biology, Colorado College, Colorado Springs, CO 80903, United States.
Gene. 2020 May 15;738:144473. doi: 10.1016/j.gene.2020.144473. Epub 2020 Feb 11.
Cytoplasmic polyadenylation element binding proteins (CPEBs) are widely conserved proteins that regulate the length of poly(A) tails in the cytoplasm, regulate translation, and regulate mRNA transport. While CPEBs are best known for regulating maternal messages in oocytes, CPEBs also have roles in many other cell types including neurons. Here we extend our knowledge of the roles of CPEBs in neurons by showing that the Drosophila CPEB-encoding gene, orb, is required for proper dendrite development in larval sensory dendritic arborization neurons. Furthermore, we provide evidence that orb is important for neuron cell fate specification.
细胞质多聚腺苷酸化元件结合蛋白（CPEBs）是广泛保守的蛋白质，可调节细胞质中多聚（A）尾的长度、调节翻译以及调节 mRNA 运输。虽然 CPEBs 最出名的是调节卵母细胞中的母本信息，但 CPEBs 在许多其他细胞类型中也有作用，包括神经元。在这里，我们通过显示果蝇 CPEB 编码基因 orb 对于幼虫感觉树突分支神经元的正常树突发育是必需的，从而扩展了我们对 CPEBs 在神经元中的作用的认识。此外，我们提供的证据表明 orb 对神经元细胞命运特化很重要。
