Department of Science and Education, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
Ecotoxicol Environ Saf. 2020 Apr 1;192:110300. doi: 10.1016/j.ecoenv.2020.110300. Epub 2020 Feb 10.
Emerging evidence has identified cardiovascular system as a potential target of Bisphenol A (BPA). Although a few studies have revealed the relationship between BPA and the risk of several cardiovascular diseases (CVD) outcomes and CVD risk factors, no published studies have investigated the link between urinary BPA and the risk of stroke.
Data were derived from the United States National Health and Nutrition Examination Surveys (NHANES), with a representative sample aged ≥20 years (n = 9139) from 2003 to 2014. We performed multivariable logistic regression model to estimate associations between quartiles and natural logarithm transformed urinary BPA concentrations and five specific CVD outcomes and total CVD.
In quartile analysis, highest level of urinary BPA was associated with increased prevalence of myocardial infarction (MI) (OR = 1.73, 95% CI = 1.11-2.69) and stroke (OR = 1.61, 95% CI = 1.09-2.36), when compared with those at the lowest quartile. Per unit (μg/g creatinine) increment in ln-transformed BPA concentration was shown to be significantly associated with 19%, 19%, 25%, 29%, 20%, and 16% increased odds ratios of prevalence of congestive heart failure, coronary heart disease (CHD), angina pectoris, MI, stroke and total CVD among total participants, respectively. Similar associations were found in males rather than in females.
We provided the premier evidence of positive relationship between urinary BPA concentration and stroke in U.S.
Urinary BPA levels were also positively correlated with congestive heart failure, CHD, angina pectoris, MI, as well as total CVD. These associations were more evident in males. Well-coordinated and prospective studies are warranted to gain the human effects of BPA on CVD.
有新证据表明，心血管系统可能是双酚 A（BPA）的作用靶点。虽然有几项研究表明 BPA 与几种心血管疾病（CVD）结局和 CVD 风险因素之间存在关联，但尚无研究调查尿液中 BPA 与中风风险之间的联系。
数据来自美国国家健康和营养调查（NHANES），2003 年至 2014 年期间对年龄≥20 岁的具有代表性的样本（n=9139）进行了研究。我们采用多变量逻辑回归模型，估计 quartiles 和自然对数转化的尿液 BPA 浓度与 5 种特定 CVD 结局和总 CVD 之间的关联。
在四分位分析中，与最低四分位数相比，尿液 BPA 水平最高的 quartile 与心肌梗死（MI）（OR=1.73，95%CI=1.11-2.69）和中风（OR=1.61，95%CI=1.09-2.36）的患病率增加相关。ln 转化的 BPA 浓度每增加一个单位（μg/g 肌酐），总参与者中充血性心力衰竭、冠心病（CHD）、心绞痛、MI、中风和总 CVD 的患病率分别增加 19%、19%、25%、29%、20%和 16%。在男性中发现了类似的关联，而在女性中则没有。
我们提供了美国人群中尿液 BPA 浓度与中风之间存在正相关关系的首要证据。
尿液 BPA 水平与充血性心力衰竭、CHD、心绞痛、MI 以及总 CVD 呈正相关。这些关联在男性中更为明显。需要进行协调一致的前瞻性研究，以了解 BPA 对 CVD 的人体影响。
