Lu Yuan, Chen Shaoxi, Jin Hongfeng, Tang Lijiang, Xia Ming
Division of Cardiac surgery, Zhejiang Hospital, Hangzhou City, China.
Division of Cardiology, Zhejiang Hospital, Hangzhou City, China.
J Appl Toxicol. 2023 Apr;43(4):500-507. doi: 10.1002/jat.4401. Epub 2022 Oct 11.
Bisphenol A (BPA) exposure may be positively associated with cardiovascular disease (CVD). For more than a past decade, exposure to bisphenol F (BPF) and bisphenol S (BPS), as substitutes for BPA, has gradually increased in the population. Whether BPF and BPS exposure are associated with CVD remains unclear. We used data from the United States National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016. A total of 3,502 participants, including 368 with CVD, were enrolled in the final analysis. Associations of BPA, BPF and BPS with CVD were determined using multivariate logistic regression analysis. The highest level of urinary BPA (≥2.5 ng/ml) was significantly associated with a higher CVD prevalence (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.08-2.3) among all participants in the quartile analysis. In stratified analyses, the highest level of urinary BPA was positively associated with CVD prevalence in males (1.86, 1.1-3.13) and the elderly population (≥60 years old) (1.89, 1.2-2.97). Higher levels of urinary BPF were positively associated with CVD prevalence in females (Q2: 1.81, 1.03-3.18; Q4: 1.73, 1.07-2.79) and in the elderly population (Q3: 1.7, 1.16-2.48). No associations were found between urinary BPS levels and CVD, regardless of whether the participants were stratified by age or sex. In conclusion, exposure to BPA or BPF was positively correlated with CVD prevalence, but an association was not found for exposure to BPS. BPF may not be as safe as assumed for human health.
双酚A（BPA）暴露可能与心血管疾病（CVD）呈正相关。在过去十多年里，作为BPA的替代品，双酚F（BPF）和双酚S（BPS）在人群中的暴露量逐渐增加。BPF和BPS暴露是否与CVD相关仍不清楚。我们使用了2013年至2016年美国国家健康与营养检查调查（NHANES）的数据。最终分析纳入了3502名参与者，其中包括368名患有CVD的参与者。使用多因素逻辑回归分析确定BPA、BPF和BPS与CVD的关联。在四分位数分析中，尿BPA最高水平（≥2.5 ng/ml）与所有参与者中较高的CVD患病率显著相关（比值比[OR]，1.58；95%置信区间[CI]，1.08 - 2.3）。在分层分析中，尿BPA最高水平与男性（1.86，1.1 - 3.13）和老年人群（≥60岁）（1.89，1.2 - 2.97）的CVD患病率呈正相关。较高水平的尿BPF与女性（Q2：1.81，1.03 - 3.18；Q4：1.73，1.07 - 2.79）和老年人群（Q3：1.7，1.16 - 2.48）的CVD患病率呈正相关。无论参与者按年龄或性别分层，均未发现尿BPS水平与CVD之间存在关联。总之，BPA或BPF暴露与CVD患病率呈正相关，但未发现BPS暴露与之相关。BPF对人类健康可能不像人们认为的那么安全。
