Department of Nutrition, School of Public Health, Sun Yat-Sen University, 74 Zhong Shan Road 2, Guangzhou 510080, China.
Department of Clinical Nutrition, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Nutrients. 2024 Sep 26;16(19):3253. doi: 10.3390/nu16193253.
Cardiovascular diseases are the primary cause of global morbidity and mortality, with cardiovascular health (CVH) remaining well below the ideal level and showing minimal improvement in the U.S. population over recent years. Bisphenol A (BPA), a pervasive environmental contaminant, has emerged as a potential contributor to adverse cardiovascular outcomes. This cross-sectional study delves into the impact of BPA exposure on achieving optimal CVH, as assessed by the Life's Essential 8 metric, among U.S. adults. Analyzing data from 6635 participants in the National Health and Nutrition Examination Survey (NHANES) collected between 2005 and 2016, BPA exposure was quantified through urinary BPA levels, while optimal CVH was defined using the American Heart Association's Life's Essential 8 criteria, scoring between 80 and 100. Multivariable logistic regression and propensity score matching were employed to evaluate the association between BPA exposure and CVH. This study reveals that individuals in the highest tertile of urinary BPA levels were 27% less likely to attain optimal CVH compared with those in the lowest tertile (OR, 0.73; 95% CI: 0.59-0.92). This negative association persisted across diverse demographics, including age, sex, and race, mirrored in the link between urinary BPA levels and health factor scores. The findings underscore the potential benefits of reducing BPA exposure in enhancing the prevalence of optimal CVH and mitigating the burden of cardiovascular disease. Given the widespread use of BPA, ongoing monitoring of BPA's impact on CVH is essential. Further studies are necessary to elucidate the long-term and causative connections between BPA and CVH. These insights contribute to understanding the complex interplay between environmental factors and CVH outcomes, informing targeted interventions to mitigate cardiovascular disease risk within the population.
心血管疾病是全球发病率和死亡率的主要原因，心血管健康（CVH）仍远低于理想水平，近年来美国人口的 CVH 改善甚微。双酚 A（BPA）作为一种普遍存在的环境污染物，已成为导致不良心血管结局的潜在因素。这项横断面研究探讨了 BPA 暴露对美国成年人通过 Life's essential 8 指标评估实现最佳 CVH 的影响。通过分析 2005 年至 2016 年期间收集的国家健康和营养检查调查（NHANES）中 6635 名参与者的数据，通过尿液 BPA 水平来量化 BPA 暴露，而最佳 CVH 则使用美国心脏协会的 Life's essential 8 标准来定义，得分在 80 到 100 之间。采用多变量逻辑回归和倾向评分匹配来评估 BPA 暴露与 CVH 之间的关联。这项研究表明，与尿液 BPA 水平最低三分位组相比，尿液 BPA 水平最高三分位组达到最佳 CVH 的可能性低 27%（OR，0.73；95%CI：0.59-0.92）。这种负相关在不同的人口统计学特征中都存在，包括年龄、性别和种族，尿液 BPA 水平与健康因素评分之间也存在这种关联。研究结果强调了减少 BPA 暴露以提高最佳 CVH 患病率和减轻心血管疾病负担的潜在益处。鉴于 BPA 的广泛使用，持续监测 BPA 对 CVH 的影响至关重要。进一步的研究对于阐明 BPA 与 CVH 之间的长期和因果关系是必要的。这些研究结果有助于了解环境因素与 CVH 结局之间的复杂相互作用，为针对人群中的心血管疾病风险实施有针对性的干预措施提供了依据。
