Muretti Mirko, Keiralla Amar, Jeffery Katie, Krasopoulos George
Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Department of Cardiothoracic Anesthesia, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
J Card Surg. 2020 Apr;35(4):923-925. doi: 10.1111/jocs.14467. Epub 2020 Feb 14.
We report a case of culture-negative aortic valve endocarditis secondary to Tropheryma whipplei infection. Our patient underwent aortic valve replacement after 4 weeks of antibiotic therapy with persistently negative blood culture results. Despite a technically uneventful operation, the patient showed continued sepsis and was unresponsive to a broad-spectrum of antibiotic therapy with subsequent multiorgan failure. He died on the 5th postoperative day, and diagnosis was established at postmortem examination. In this case report, we discuss the diagnosis and treatment of a rare type of endocarditis caused by T. whipplei.
我们报告一例由惠普尔嗜组织细胞菌感染引起的血培养阴性的主动脉瓣心内膜炎病例。我们的患者在接受了4周抗生素治疗后血培养结果持续为阴性，随后接受了主动脉瓣置换术。尽管手术过程顺利，但患者仍持续存在败血症，对广谱抗生素治疗无反应，随后出现多器官功能衰竭。他在术后第5天死亡，死后尸检确诊。在本病例报告中，我们讨论了由惠普尔嗜组织细胞菌引起的罕见类型心内膜炎的诊断和治疗。
