Faculty of Pharmaceutical Sciences, University François Rabelais, Tours, France.
Arabic Science Archive - ArabiXiv (https://arabixiv.org).
Curr Opin Biotechnol. 2020 Feb;61:209-216. doi: 10.1016/j.copbio.2020.01.004. Epub 2020 Feb 12.
Millions of people around the world suffer from heavy social and health burdens related to HIV/AIDS and its associated opportunistic infections. To reduce these burdens, preventive and therapeutic vaccines are required. Effective HIV vaccines have been under investigation for several decades using different animal models. Potential plant-made HIV vaccine candidates have also gained attention in the past few years. In addition to this, broadly neutralizing antibodies produced in plants which can target conserved viral epitopes and neutralize mutating HIV strains have been identified. Numerous epitopes of envelope glycoproteins and capsid proteins of HIV-1 are a part of HIV therapy. Here, we discuss some recent findings aiming to produce anti-HIV-1 recombinant proteins in engineered plants for AIDS prophylactics and therapeutic treatments.
全球数百万人因 HIV/AIDS 及其相关机会性感染而承受着沉重的社会和健康负担。为了减轻这些负担，需要预防和治疗性疫苗。几十年来，人们一直在使用不同的动物模型研究有效的 HIV 疫苗。在过去的几年中，潜在的植物制造的 HIV 疫苗候选物也引起了关注。除此之外，还在植物中产生了可以针对保守病毒表位并中和发生突变的 HIV 株的广泛中和抗体。HIV-1 的包膜糖蛋白和衣壳蛋白的许多表位都是 HIV 治疗的一部分。在这里，我们讨论了一些旨在利用工程植物生产抗 HIV-1 重组蛋白以用于 AIDS 预防和治疗的最新发现。
