Jensh R P, Brent R L
Department of Anatomy, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Radiat Res. 1988 Dec;116(3):416-26.
Seventy pregnant adult Wistar strain rats were randomly assigned to 1 of 12 exposure groups; 9th or 17th day irradiation at the 0-, 0.1-, 0.2-, 0.4-, 0.6-, or 0.8-Gy dosage level. On the first day of postnatal life, litters were reduced to a maximum of eight pups per litter. A total of 508 pups were observed for the age of acquisition of five reflexes (air righting, surface righting, visual placing, negative geotaxis, auditory startle) and the appearance of four physiologic markers (pinna detachment, eye opening, vaginal opening, testes descent). A dose-response relationship for alterations in reflex acquisition and physiologic marker appearance was observed due to exposure above 0.2 Gy on the 17th day of gestation. Therefore, 0.2 to 0.4-Gy exposure may represent a threshold range for exposure on the 17th day using these postnatal parameters.
70只成年怀孕Wistar品系大鼠被随机分配到12个暴露组中的1组；在妊娠第9天或第17天，以0、0.1、0.2、0.4、0.6或0.8 Gy的剂量水平进行辐照。在出生后的第一天，每窝幼崽最多减少到8只。总共观察了508只幼崽，以观察其获得五种反射（空中翻正、表面翻正、视觉定位、负趋地性、听觉惊吓）的年龄以及四种生理指标（耳廓分离、睁眼、阴道口开放、睾丸下降）的出现情况。由于在妊娠第17天接受0.2 Gy以上的辐照，观察到反射获得和生理指标出现的改变存在剂量反应关系。因此，使用这些出生后参数，0.2至0.4 Gy的辐照剂量可能代表妊娠第17天暴露的阈值范围。
