Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Van der Boechorststraat 9, 1081 BT, Amsterdam, The Netherlands.
The Hopkins Centre, Menzies Health Institute Queensland, Griffith University, Brisbane & Gold Coast, Australia.
J Headache Pain. 2020 Feb 14;21(1):16. doi: 10.1186/s10194-020-1083-z.
People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity throughout the migraine cycle. Therefore, this study aimed (1) to comprehensively assess mechanical sensitivity in both cephalic and extra-cephalic regions during the preictal, ictal, postictal and interictal phases; and (2) to compare these findings with mechanical sensitivity at corresponding time-points and locations in healthy participants.
According to sample size calculations, 19 people with migraine and 19 matched healthy volunteers participated in a prospective longitudinal study. Pressure pain thresholds were evaluated in three cephalic regions (temporalis, upper trapezius and C1 paraspinal muscles) and two extra-cephalic regions (extensor carpi radialis and tibialis anterior muscle) with a digital algometer during the four phases of the migraine cycle in people with migraine and at corresponding intervals and locations in healthy participants. Linear mixed model analyses with a random intercept were used.
People with migraine had increased mechanical sensitivity in cephalic and extra-cephalic regions in all phases of the migraine cycle compared to healthy participants. Furthermore, this mechanical sensitivity was more severe in the preictal, ictal and postictal phase compared to the interictal phase in cephalic and extra-cephalic regions.
People with migraine have localised as well as widespread mechanical sensitivity compared to healthy participants. This sensitivity is even more pronounced immediately before, during and after a migraine attack.
偏头痛患者存在局部（即头部）机械敏感性。关于广泛（即头部以外）机械敏感性以及偏头痛周期中机械敏感性的变化，目前尚存在不确定性。因此，本研究旨在：（1）全面评估在先兆期、发作期、发作后期和无发作期，头部和头部以外区域的机械敏感性；（2）将这些发现与健康参与者相应时间点和部位的机械敏感性进行比较。
根据样本量计算，19 名偏头痛患者和 19 名匹配的健康志愿者参与了一项前瞻性纵向研究。使用数字压痛计在偏头痛患者偏头痛周期的四个阶段的三个头部区域（颞肌、上斜方肌和 C1 棘突旁肌肉）和两个头部以外区域（伸腕肌和胫骨前肌）评估压痛阈值，并在健康参与者的相应时间点和部位进行评估。采用随机截距线性混合模型分析。
与健康参与者相比，偏头痛患者在偏头痛周期的所有阶段的头部和头部以外区域均存在机械敏感性增加。此外，与无发作期相比，在先兆期、发作期和发作后期，头部和头部以外区域的机械敏感性更为严重。
与健康参与者相比，偏头痛患者存在局部和广泛的机械敏感性。这种敏感性在偏头痛发作前、发作中和发作后更为明显。
