D'Alessandro N, Rausa L, Crescimanno M
Istituto di Farmacologia, Messina, Italy.
Res Commun Chem Pathol Pharmacol. 1988 Oct;62(1):19-30.
Some parameters of free radical generation were studied in the hearts of CD 1 mice at short time intervals after the administration of Doxorubicin (15 mg/Kg i.v.) or Isoproterenol (80 mg/Kg s.c.). The two drugs consistently caused a decrease in cardiac reduced glutathione. Isoproterenol significantly increased in vivo H2O2 production by the heart at all the intervals taken into consideration, i.e., 5, 8, 12 and 16 hours after its administration. However, Doxorubicin did not significantly modify H2O2 generation at the same hours. These findings suggest that an increase in H2O2 production may not be involved in the oxidative stress caused by the anthracyclines at cardiac level.
在给CD1小鼠静脉注射阿霉素（15mg/Kg）或皮下注射异丙肾上腺素（80mg/Kg）后的短时间间隔内，研究了其心脏中自由基生成的一些参数。这两种药物均持续导致心脏中还原型谷胱甘肽减少。在考虑的所有时间间隔，即异丙肾上腺素给药后5、8、12和16小时，其显著增加了心脏在体内的H2O2生成。然而，阿霉素在相同时间并未显著改变H2O2的生成。这些发现表明，H2O2生成的增加可能与蒽环类药物在心脏水平引起的氧化应激无关。
