Doroshow J H, Locker G Y, Baldinger J, Myers C E
Res Commun Chem Pathol Pharmacol. 1979 Nov;26(2):285-95.
The effect of the antitumor antibiotic doxorubicin on glutathione and glutathione disulfide levels in mouse heart and liver has been evaluated. The glutathione content of hepatic and cardiac tissue from saline-treated controls exhibited a statistically significant diurnal variation. Doxorubicin administration produced a dose-related decrease in hepatic glutathione which was not blocked by pretreatment with the free radical scavenger alpha-tocopherol; a lesser drop in cardiac glutathione was also documented. These changes may play an important role in the metabolism and toxicity of doxorubicin.
已评估了抗肿瘤抗生素阿霉素对小鼠心脏和肝脏中谷胱甘肽及二硫化谷胱甘肽水平的影响。生理盐水处理的对照组肝脏和心脏组织中的谷胱甘肽含量呈现出具有统计学意义的昼夜变化。给予阿霉素会使肝脏谷胱甘肽含量出现剂量相关的下降，且这种下降未被自由基清除剂α-生育酚预处理所阻断；心脏谷胱甘肽也有较小程度的下降。这些变化可能在阿霉素的代谢和毒性中起重要作用。
