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同期主动脉瓣和二尖瓣手术,联合或不联合三尖瓣修复术。

Combined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair.

机构信息

Section of Cardiac Surgery, Yale University School of Medicine, New Haven, Connecticut.

Section of Cardiac Surgery, Yale University School of Medicine, New Haven, Connecticut.

出版信息

Semin Thorac Cardiovasc Surg. 2020;32(4):665-672. doi: 10.1053/j.semtcvs.2020.02.010. Epub 2020 Feb 12.

DOI:10.1053/j.semtcvs.2020.02.010
PMID:32060011
Abstract

There is limited clinical evidence on when to address tricuspid regurgitation in patients with aortic and mitral valve disease requiring surgical intervention. In this study, we aimed to investigate the potential added value of performing a tricuspid valve repair concomitantly in patients requiring double valve surgery (DVS) of the aortic and mitral valves. We reviewed 223 cases of multivalve surgery from 2011 to 2016. In this single-institution series, 190 underwent DVS in aortic and mitral positions and 33 had triple valve surgery in aortic, mitral, and tricuspid positions. Preoperative and postoperative echocardiograms were evaluated to determine changes in valve function. A logistic regression model was performed to assess relationship of patient comorbidities and type of valve operations to perioperative adverse events. Mid-term survival was similar between the 2 groups (P = 0.541). Compared to DVS, TVS was not associated with an increased risk of perioperative adverse events, including need for pacemaker or mortality on multivariable analysis. Within the DVS subgroup, 19.8% of patients experienced improvement in tricuspid valve function with decrease in the degree of tricuspid regurgitation within a 6-month postoperative follow-up. Our study indicates that repairing the tricuspid valve while addressing the aortic and mitral valves does not pose significant additional risk. The observed improvement of the degree of tricuspid regurgitation without tricuspid operation suggests the need to further define subpopulations of patients with multivalvular disease.

摘要

关于需要手术干预的主动脉瓣和二尖瓣疾病患者何时解决三尖瓣反流的临床证据有限。在这项研究中,我们旨在研究在需要进行主动脉瓣和二尖瓣双瓣手术(DVS)的患者中同时进行三尖瓣修复的潜在附加价值。我们回顾了 2011 年至 2016 年的 223 例多瓣膜手术。在该单中心系列中,190 例行主动脉瓣和二尖瓣 DVS,33 例行主动脉瓣、二尖瓣和三尖瓣三瓣手术。评估术前和术后超声心动图以确定瓣膜功能的变化。进行逻辑回归模型以评估患者合并症和瓣膜手术类型与围手术期不良事件的关系。两组的中期生存率相似(P = 0.541)。与 DVS 相比,TVS 与围手术期不良事件(包括需要起搏器或多变量分析中的死亡率)的风险增加无关。在 DVS 亚组中,19.8%的患者在术后 6 个月的随访中经历了三尖瓣功能的改善,三尖瓣反流程度降低。我们的研究表明,在处理主动脉瓣和二尖瓣的同时修复三尖瓣不会带来显著的额外风险。在没有三尖瓣手术的情况下观察到三尖瓣反流程度的改善表明需要进一步确定多瓣膜疾病患者的亚组。

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