Kaplan Mustafa, Duzenli Tolga, Tanoglu Alpaslan, Cakir Guney Basak, Onal Tastan Yesim, Bicer Hatice Selcen
Department of Internal Medicine, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
Department of Gastroenterology, Hitit University Erol Olcok Training and Research Hospital, Corum, Turkey.
Wien Klin Wochenschr. 2020 Apr;132(7-8):182-187. doi: 10.1007/s00508-020-01618-9. Epub 2020 Feb 14.
To investigate the prognostic value of the presepsin:albumin ratio and C‑reactive protein:albumin ratio in patients with sepsis in the intensive care unit (ICU).
A total of 228 (129 males and 99 females) patients with newly diagnosed sepsis were included in the study. The relationship between the C‑reactive protein:albumin ratio, presepsin:albumin ratio, clinicopathologic parameters, and overall survival were investigated. The associations between C‑reactive protein:albumin ratio and presepsin:albumin ratio were evaluated alongside other inflammation-based prognostic scores such as quick Sepsis Related Organ Failure Assessment (qSOFA).
The presepsin:albumin ratio was significantly higher in non-survivors (p < 0.01). Patients with a high presepsin:albumin ratio had worse overall survival compared with patients with high C‑reactive protein:albumin ratio levels (p < 0.001).
Presepsin and presepsin:albumin ratio are markers of adverse prognosis in patients with sepsis and are superior to C‑reactive protein and C‑reactive protein:albumin ratio for this purpose. Presepsin:albumin ratio may be a novel marker of poor prognosis in patients with sepsis in intensive care units.
探讨前降钙素与白蛋白比值及C反应蛋白与白蛋白比值在重症监护病房（ICU）脓毒症患者中的预后价值。
本研究共纳入228例（男129例，女99例）新诊断的脓毒症患者。研究了C反应蛋白与白蛋白比值、前降钙素与白蛋白比值、临床病理参数与总生存率之间的关系。将C反应蛋白与白蛋白比值和前降钙素与白蛋白比值之间的关联与其他基于炎症的预后评分（如快速脓毒症相关器官功能衰竭评估（qSOFA））一起进行评估。
非存活者的前降钙素与白蛋白比值显著更高（p＜0.01）。与C反应蛋白与白蛋白比值高的患者相比，前降钙素与白蛋白比值高的患者总生存率更差（p＜0.001）。
前降钙素及前降钙素与白蛋白比值是脓毒症患者不良预后的标志物，在此方面优于C反应蛋白及C反应蛋白与白蛋白比值。前降钙素与白蛋白比值可能是重症监护病房脓毒症患者预后不良的新标志物。
