Jongvanitpak Rasamee, Vichyanond Pakit, Jirapongsananuruk Orathai, Visitsunthorn Nualanong, Pacharn Punchama
Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Asian Pac J Allergy Immunol. 2022 Dec;40(4):407-413. doi: 10.12932/AP-160519-0564.
Allergic conjunctivitis (AC) is the most common ocular condition in allergic children. In tropical countries, the study about the clinical features and outcome of treatment is very limited.
To review clinical characteristics and outcomes of treatment in children with ocular allergy.
Children with history of AC were classified to seasonal allergic conjunctivitis (SAC), perennial allergic conjunctivitis (PAC), vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC). The clinical history and outcome of treatment were recorded.
One hundred and sixty-four children were recruited. PAC was the most common type (61.6%), followed by SAC (21.3%), VKC (12.2%), and AKC (4.9%). Male preponderance was found in all groups. Mean age of onset was 6.8 ± 2.8 years. Allergic rhinitis was the most common co-morbidity (97.6%). The common sensitized allergen is house-dust mites (86.1%). Standard treatments in all groups were natural tear and topical olopatadine. Add-on medications were usually needed in severe types of AC (VKC, AKC). History of topical corticosteroid use was 68.8% and 12.5% in VKC and AKC, respectively. All of them can discontinue topical corticosteroid when topical tacrolimus was applied. The overall remission was found 35% in VKC group and 63% in AKC group. The median duration of treatment was 20.5 months in VKC group and 11 months in AKC group.
most Thai children with AC sensitized to house-dust mites. In severe forms of AC, most patients needed addon medication. The use of topical calcineurin inhibitor as an add-on therapy can decrease the use of topical corticosteroid.
过敏性结膜炎（AC）是过敏性儿童中最常见的眼部疾病。在热带国家，关于其临床特征及治疗结果的研究非常有限。
回顾眼部过敏儿童的临床特征及治疗结果。
有AC病史的儿童被分为季节性过敏性结膜炎（SAC）、常年性过敏性结膜炎（PAC）、春季角结膜炎（VKC）和特应性角结膜炎（AKC）。记录临床病史及治疗结果。
共招募了164名儿童。PAC是最常见的类型（61.6%），其次是SAC（21.3%）、VKC（12.2%）和AKC（4.9%）。所有组均以男性居多。平均发病年龄为6.8±2.8岁。过敏性鼻炎是最常见的合并症（97.6%）。常见的致敏变应原是屋尘螨（86.1%）。所有组的标准治疗都是使用天然泪液和局部用奥洛他定。严重类型的AC（VKC、AKC）通常需要加用其他药物。VKC和AKC局部使用皮质类固醇的比例分别为68.8%和12.5%。当应用局部他克莫司时，所有患者均可停用局部皮质类固醇。VKC组的总体缓解率为35%，AKC组为63%。VKC组的中位治疗持续时间为20.5个月，AKC组为11个月。
大多数泰国AC儿童对屋尘螨过敏。在严重形式的AC中，大多数患者需要加用药物。使用局部钙调神经磷酸酶抑制剂作为附加治疗可减少局部皮质类固醇的使用。
