肥胖、胰岛素与癌症之间的机制联系。
Mechanistic Links between Obesity, Insulin, and Cancer.
作者信息
Perry Rachel J, Shulman Gerald I
机构信息
Departments of Internal Medicine and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520-8020, USA.
Departments of Internal Medicine and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520-8020, USA.
出版信息
Trends Cancer. 2020 Feb;6(2):75-78. doi: 10.1016/j.trecan.2019.12.003. Epub 2020 Jan 14.
Abstract
Obesity and type 2 diabetes (T2D) increase the prevalence and worsen the prognosis of more than a dozen tumor types; however, the mechanism for this association remains hotly debated. Here we discuss a potential role for insulin as the key hormonal mediator of tumor metabolism and growth in obesity-associated insulin resistance.
摘要
肥胖和2型糖尿病（T2D）会增加十几种肿瘤类型的患病率并使预后恶化；然而，这种关联的机制仍存在激烈争论。在此，我们讨论胰岛素作为肥胖相关胰岛素抵抗中肿瘤代谢和生长的关键激素介质的潜在作用。
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