Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
J Allergy Clin Immunol Pract. 2020 Jun;8(6):1994-2003.e2. doi: 10.1016/j.jaip.2020.01.060. Epub 2020 Feb 28.
Primary eosinophilic gastrointestinal diseases (EGIDs) are increasingly described disorders that include eosinophilic esophagitis (EoE), eosinophilic gastritis, gastroenteritis, and colitis. The exact epidemiology of nonesophageal EGIDs (non-EoE EGIDs) is still unclear.
To evaluate the epidemiology of non-EoE EGIDs in adults and children referred to outpatient clinics for gastrointestinal symptoms.
We conducted a systematic review and meta-analysis using a protocol registered and published with the international prospective register of systematic reviews (PROSPERO CRD42018111437). We searched PubMed, EMBASE, Web of Science, Scopus, and CINAHL for cohort or cross-sectional studies published since 1990, evaluating the incidence and prevalence of non-EoE EGIDs. We assessed study quality and risk of bias using items derived from the Strengthening the Reporting of Observational Studies in Epidemiology statement.
A total of 576 articles were identified. Ten studies with 13,377 participants were included in the analysis, with the results showing high heterogeneity. No significant publication bias was found. The overall prevalence of non-EoE EGIDs in patients with gastrointestinal symptoms was 1.9% (95% confidence interval: 0.575-3.894; I = 92.72%; P < .001). Because none of the examined studies were prospectively designed, incidence rates could not be determined.
More prospective, large-scale, multicenter studies are needed to evaluate reported data and to further investigate the epidemiology of non-EoE EGIDs and their possible risk factors and comorbidities.
原发性嗜酸性粒细胞性胃肠道疾病（EGID）是一种越来越常见的疾病，包括嗜酸性食管炎（EoE）、嗜酸性胃炎、胃肠炎和结肠炎。非嗜酸性食管炎（非 EoE EGID）的确切流行病学仍不清楚。
评估门诊胃肠道症状患者中非 EoE EGID 的流行病学。
我们使用已在国际前瞻性系统评价注册库（PROSPERO CRD42018111437）注册和发表的方案进行了系统评价和荟萃分析。我们检索了 PubMed、EMBASE、Web of Science、Scopus 和 CINAHL，以评估自 1990 年以来发表的评估非 EoE EGID 的发病率和患病率的队列或横断面研究。我们使用源自观察性研究的强化报告标准（Strengthening the Reporting of Observational Studies in Epidemiology statement）的项目评估研究质量和偏倚风险。
共确定了 576 篇文章。纳入了 10 项研究，共 13377 名参与者，结果显示高度异质性。未发现明显的发表偏倚。胃肠道症状患者中非 EoE EGID 的总体患病率为 1.9%（95%置信区间：0.575-3.894；I²=92.72%；P<0.001）。由于没有一项研究是前瞻性设计的，因此无法确定发病率。
需要更多前瞻性、大规模、多中心的研究来评估报告的数据，并进一步研究非 EoE EGID 的流行病学及其可能的危险因素和合并症。
