Department of Genetics, Friedrich-Alexander-University Erlangen-Nürnberg, Germany.
Biochim Biophys Acta Gene Regul Mech. 2020 Mar;1863(3):194503. doi: 10.1016/j.bbagrm.2020.194503. Epub 2020 Feb 19.
The highly leukemogenic MLL fusion proteins have a unique mechanism of action. This review summarizes the current knowledge of how MLL fusions interact with the transcriptional machinery and it proposes a hypothesis how these proteins modify transcriptional control to act as transcriptional amplifiers causing runaway production of certain RNAs that transform hematopoietic cells.
高致白血病性的 MLL 融合蛋白具有独特的作用机制。这篇综述总结了目前关于 MLL 融合蛋白如何与转录机制相互作用的知识，并提出了一个假设，即这些蛋白如何修饰转录控制，作为转录放大器，导致某些 RNA 的失控产生，从而转化造血细胞。
