Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Lung Cancer. 2020 Apr;142:13-19. doi: 10.1016/j.lungcan.2020.01.020. Epub 2020 Feb 3.
This study is aimed to analyze the survival differences among patients with lung basaloid squamous cell carcinoma (BSCC), keratinizing squamous cell carcinoma (KSCC), and nonkeratinizing squamous cell carcinoma (NKSCC), and explore the prognostic factors of patients with lung BSCC.
We searched the information of 4743 patients with lung SCC between 2005 and 2014 from the SEER database. Propensity score matching (PSM) was used to adjust confounding factors. The overall survival (OS), cancer-specific survival (CSS), and cumulative incidence of cancer-specific mortality (CSM) were estimated with a comparative analysis. A competing risks regression model was conducted to identify the prognostic factors of lung BSCC.
After PSM, patients with lung BSCC had a higher CSS rate than those with lung KSCC or NKSCC (5-year CSS rate: 50.4 % vs. 37.7 % vs. 38.5 %, p = 0.033 and p = 0.033). The cumulative incidence of CSM was lower for patients with lung BSCC than those with lung KSCC or NKSCC (5-year CSM rate: 46.4 % vs. 56.9 % vs. 56.4 %, p = 0.046 and p = 0.042), which were similar to the results before PSM. As for patients with lung KSCC and NKSCC, there was no survival differences between them (5-year CSS rate: 37.7 % vs. 38.5 %, p = 0.997). The competing risks regression analysis showed that T stage, N stage, M stage and surgery were independent prognostic factors for patients with lung BSCC (all p < 0.05).
Patients with lung BSCC had a better survival than those with lung KSCC or NKSCC, while no survival differences were found between lung KSCC and NKSCC. T stage, N stage, M stage and surgery were independent prognostic factors for patients with lung BSCC.
本研究旨在分析肺基底细胞样鳞癌（BSCC）、角化型鳞癌（KSCC）和非角化型鳞癌（NKSCC）患者的生存差异，并探讨肺 BSCC 患者的预后因素。
我们从 SEER 数据库中检索了 2005 年至 2014 年间 4743 例肺鳞癌患者的信息。采用倾向评分匹配（PSM）调整混杂因素。采用比较分析估计总生存期（OS）、癌症特异性生存期（CSS）和癌症特异性死亡率的累积发生率（CSM）。采用竞争风险回归模型识别肺 BSCC 的预后因素。
PSM 后，肺 BSCC 患者的 CSS 率高于肺 KSCC 或 NKSCC 患者（5 年 CSS 率：50.4%比 37.7%比 38.5%，p=0.033 和 p=0.033）。肺 BSCC 患者的 CSM 累积发生率低于肺 KSCC 或 NKSCC 患者（5 年 CSM 率：46.4%比 56.9%比 56.4%，p=0.046 和 p=0.042），与 PSM 前的结果相似。对于肺 KSCC 和 NKSCC 患者，两者之间的生存差异无统计学意义（5 年 CSS 率：37.7%比 38.5%，p=0.997）。竞争风险回归分析显示，T 分期、N 分期、M 分期和手术是肺 BSCC 患者的独立预后因素（均 p<0.05）。
肺 BSCC 患者的生存情况优于肺 KSCC 或 NKSCC 患者，而肺 KSCC 和 NKSCC 患者之间的生存差异无统计学意义。T 分期、N 分期、M 分期和手术是肺 BSCC 患者的独立预后因素。
