脉络膜血管指数作为 Fuchs 葡萄膜炎综合征慢性程度的参数。
Choroid vascularity index as a parameter for chronicity of Fuchs' uveitis syndrome.
机构信息
Ophthalmology Department, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.
出版信息
Int Ophthalmol. 2020 Jun;40(6):1429-1437. doi: 10.1007/s10792-020-01309-4. Epub 2020 Feb 15.
PURPOSE
This study aimed to compare the choroidal vascularity index (CVI) of eyes having Fuchs' uveitis syndrome (FUS) with healthy fellow eyes (N).
METHODS
This prospective, cross-sectional study included unilateral FUS cases and an age- and gender-matched healthy control group. Thirty-nine participants were included in the FUS group, and 24 age- and gender-matched individuals were randomly selected for the control group. Endothelial cell density (ECD) was measured using Tomey specular microscopy. Spectral-domain optical coherence tomography was used to acquire the choroidal images, and binarization was applied to the images. Two blinded investigators analyzed the CVI in both eyes of the FUS cases and the right eyes of the healthy control group.
RESULTS
CVI was found to be significantly decreased in FUS (p < 0.001). Additionally, ECD had a strong positive correlation with CVI (r = 0.383, p = 0.008).
CONCLUSION
CVI may provide information about the chronicity of the disease.
目的
本研究旨在比较 Fuchs 葡萄膜炎综合征（FUS）患眼与健康对侧眼（N）的脉络膜血管指数（CVI）。
方法
这是一项前瞻性、横断面研究，纳入了单侧 FUS 病例和年龄及性别匹配的健康对照组。FUS 组纳入 39 名参与者，对照组随机选择 24 名年龄和性别匹配的个体。使用 Tomey 共焦显微镜测量内皮细胞密度（ECD）。使用频域光学相干断层扫描获取脉络膜图像，并对图像进行二值化处理。两名盲法研究者分析了 FUS 病例双眼和健康对照组右眼的 CVI。
结果
FUS 组的 CVI 显著降低（p<0.001）。此外，ECD 与 CVI 呈强正相关（r=0.383，p=0.008）。
结论
CVI 可能提供有关疾病慢性程度的信息。
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