Zhou Fang-Yue, Li Yi-Sha, Guo Xingneng, Shi Xiutong, Wu Ke, Zheng Jing-Wei, Li Xia-Xin, Wu Jiaqing, Liu Ruru, Dai Ma-Li, Huang Xiu-Feng, Hou Fang, Lin Dan, Wang Yu-Qin
School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
School of Optometry, Tianjin Vocational Institute, Tianjin, China.
Front Med (Lausanne). 2022 May 19;9:850435. doi: 10.3389/fmed.2022.850435. eCollection 2022.
To investigate the deficits in contrast sensitivity in patients with Fuchs uveitis syndrome (FUS) and to explore the potential relationship between contrast sensitivity and ocular structure.
In this prospective study, 25 patients with FUS and 30 healthy volunteers were recruited. Eyes were divided into three groups: FUS-affected eyes (AE), fellow eyes (FE), and healthy eyes. The contrast sensitivity function (CSF) of all participants was evaluated using the quick CSF (qCSF) method. Fundus photographs were collected for the analysis of refractive media, and vascular density (VD) was assessed using optical coherence tomography angiography (OCTA). Data were analyzed and compared using the generalized estimating equation (GEE).
The CSF of AE was significantly lower than that of FE and controls, while no significant difference was observed between FE and controls. Contrast sensitivity was negatively correlated with the grade of haze. No significant correlation was found between visual function and VDs in FUS eyes.
We found that the CSF of FUS-affected eyes was significantly reduced, and the visual impairment was predominantly caused by the refractive media turbidity.
研究富克斯葡萄膜炎综合征（FUS）患者的对比敏感度缺陷，并探讨对比敏感度与眼部结构之间的潜在关系。
在这项前瞻性研究中，招募了25例FUS患者和30名健康志愿者。眼睛分为三组：FUS患眼（AE）、对侧眼（FE）和健康眼。使用快速对比敏感度函数（qCSF）方法评估所有参与者的对比敏感度函数（CSF）。收集眼底照片用于屈光介质分析，并使用光学相干断层扫描血管造影（OCTA）评估血管密度（VD）。使用广义估计方程（GEE）对数据进行分析和比较。
AE的CSF显著低于FE和对照组，而FE和对照组之间未观察到显著差异。对比敏感度与 haze等级呈负相关。在FUS眼中，视觉功能与VDs之间未发现显著相关性。
我们发现FUS患眼的CSF显著降低，视力损害主要由屈光介质混浊引起。
