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[撤回:深圳34例2019新型冠状病毒感染儿童的临床和流行病学特征]

[Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen].

作者信息

Wang X F, Yuan J, Zheng Y J, Chen J, Bao Y M, Wang Y R, Wang L F, Li H, Zeng J X, Zhang Y H, Liu Y X, Liu L

机构信息

Department of Pediatrics, the Third People's Hospital of Shenzhen, Shenzhen 518020, China.

Department of Infectious Disease, the Third People's Hospital of Shenzhen, Shenzhen 518020, China.

出版信息

Zhonghua Er Ke Za Zhi. 2020 Feb 17;58(0):E008. doi: 10.3760/cma.j.issn.0578-1310.2020.0008.

Abstract

To describe the characteristics of clinical manifestations and epidemiology of children with 2019 novel coronavirus (2019-nCoV) infection. All 34 children with laboratory-confirmed 2019-nCoV infection by quantitative real-time reverse transcription-PCR through nasopharyngeal swab specimens were admitted to the Third People's Hospital of Shenzhen from January 19 to Febuary 7, 2020. Clinical data and epidemiological history of these patients were retrospectively collected and analyzed. Among the 34 cases, 14 were males, and 20 were females. The median age was 8 years and 11 months. No patients had underlying diseases. There were 28 children (82%) related with a family cluster outbreak. There were 26 children (76%) with a travel or residence history in Hubei Province. These patients could be categorized into different clinical types, including 22 (65%) common cases, 9 (26%) mild cases and 3 (8.8%) asymptomatic cases. No severe or critical cases were identified. The most common symptoms were fever (17 cases, 50%) and cough (13 cases, 38% ). In the 34 cases, the white blood cell counts of 28 cases (82%) were normal. Five cases had white blood cell counts more than 10×10(9)/L. One case had white blood cell counts less than 4×10(9)/L. Neutropenia and lymphopenia was found in one case, respectively. C-reactive protein levels and erythrocyte sedimentation rates were elevated in 1 and 5 case, respectively. Elevated procalcitonin was found in 1 case and D-Dimer in 3 cases. The levels of lactic dehydrogenase (LDH) were more than 400 U/L in 10 cases. The CT images of these patients showed bilateral multiple patchy or nodular ground-glass opacities and/or infiltrating shadows in middle and outer zone of the lung or under the pleura. Twenty patients were treated with lopinavir and ritonavir. Glucocorticoids and immunoglobulin were not used in any cases. All the cases improved and were discharged from hospital. Further following up was need. The clinical manifestations in children with 2019-nCoV infection are non-specific and are milder than that in adults. Chest CT scanning is heplful for early diagnosis. Children's infection is mainly caused by family cluster outbreak and imported cases. Family daily prevention is the main way to prevent 2019-nCoV infection.

摘要

描述2019新型冠状病毒(2019-nCoV)感染儿童的临床表现及流行病学特征。2020年1月19日至2月7日,深圳市第三人民医院收治了34例经鼻咽拭子标本定量实时逆转录PCR实验室确诊为2019-nCoV感染的儿童。回顾性收集并分析了这些患者的临床资料和流行病学史。34例病例中,男性14例,女性20例。中位年龄为8岁11个月。所有患者均无基础疾病。28例(82%)患儿与家庭聚集性疫情有关。26例(76%)患儿有湖北省旅行或居住史。这些患者可分为不同临床类型,包括普通型22例(65%)、轻型9例(26%)和无症状感染者3例(8.8%)。未发现重型或危重型病例。最常见症状为发热(17例,50%)和咳嗽(13例,38%)。34例患者中,28例(82%)白细胞计数正常。5例白细胞计数高于10×10⁹/L。1例白细胞计数低于4×10⁹/L。分别有1例出现中性粒细胞减少和淋巴细胞减少。C反应蛋白水平升高1例,红细胞沉降率升高5例。降钙素原升高1例,D-二聚体升高3例。10例乳酸脱氢酶(LDH)水平高于400 U/L。这些患者的胸部CT图像显示双肺多发斑片状或结节状磨玻璃影和/或肺中外带及胸膜下浸润影。20例患者接受了洛匹那韦和利托那韦治疗。所有病例均未使用糖皮质激素和免疫球蛋白。所有病例病情均有改善并出院。仍需进一步随访。2019-nCoV感染儿童的临床表现无特异性,且较成人症状轻。胸部CT扫描有助于早期诊断。儿童感染主要由家庭聚集性疫情和输入病例引起。家庭日常预防是预防2019-nCoV感染的主要途径。

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