You Y Y, Song Y, Wang M H, Zhang L L, Bai W, Yu W Y, Yu Y Q, Kou C G
Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China; Health Education Division, Center for Chronic Disease Control, Nanshan District, Shenzhen 518000, China.
Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Jan 10;41(1):74-78. doi: 10.3760/cma.j.issn.0254-6450.2020.01.014.
To investigate the relationship between exposure to famine in fetus and infant period and the risks for hypertension in adulthood. A total of 5 960 participants born between 1956 and 1965 were included in the study and were divided into unexposed group (1963-1965), fetal exposed group (1959-1961), early- childhood exposed group (1956-1958) and transitional group (1962). Logistic regression model was used to explore the association between famine exposure in early life and the risk for hypertension in adulthood. Both the fetal exposure and the early-childhood exposure were the risk factors for hypertension in adulthood (=1.249, 95: 1.049-1.486 and =1.360, 95: 1.102-1.679). Meanwhile, in rural area, compared with unexposed group, the fetal exposure (=1.401, 95: 1.091-1.798) and the early-childhood exposure (=1.460, 95: 1.145-1.862) were also associated with a greater risk of hypertension in adulthood. In addition, fetal exposure and early-childhood exposure to famine in women were associated with 36.0 and 31.9 increased risks for hypertension (95: 7.8-71.7 and 95: 4.8-66.0) according to the stratified analysis. Fetal exposure to famine might increase the risk for hypertension in adulthood.
探讨胎儿期和婴儿期暴露于饥荒与成年后患高血压风险之间的关系。该研究共纳入了5960名在1956年至1965年之间出生的参与者，并将其分为未暴露组（1963 - 1965年）、胎儿暴露组（1959 - 1961年）、幼儿期暴露组（1956 - 1958年）和过渡组（1962年）。采用逻辑回归模型探讨生命早期暴露于饥荒与成年后患高血压风险之间的关联。胎儿期暴露和幼儿期暴露均为成年后患高血压的危险因素（比值比 = 1.249，95%置信区间：1.049 - 1.486；比值比 = 1.360，95%置信区间：1.102 - 1.679）。同时，在农村地区，与未暴露组相比，胎儿期暴露（比值比 = 1.401，95%置信区间：1.091 - 1.798）和幼儿期暴露（比值比 = 1.460，95%置信区间：1.145 - 1.862）也与成年后患高血压的更高风险相关。此外，根据分层分析，女性胎儿期暴露于饥荒和幼儿期暴露于饥荒分别使高血压风险增加36.0和31.9（95%置信区间：7.8 - 71.7和95%置信区间：4.8 - 66.0）。胎儿期暴露于饥荒可能会增加成年后患高血压的风险。
