Garland-Thomson Rosemarie
Perspect Biol Med. 2020;63(1):28-43. doi: 10.1353/pbm.2020.0002.
This article considers the existential and eugenic risks of gene editing with CRISPR-Cas9. It brings forward epistemological and phenomenological questions concerning what CRISPR technology suggests about the limits of being human. By illuminating the paradoxical relationship between our "then self" and "now self," it considers the fragility of our individual and collective future-making endeavors. To do this, the article offers an overview of the existential dilemmas facing modern subjects, a history of eugenics and the ideology of health, a meditation on the limits of human knowledge, and an explication of the cultural work of metaphor. It argues for the benefits of human variation for individuals and communities and concludes by calling for an attitude of humility and restraint to guide the development and implementation of humane technologies rather than genetic manipulation technologies that aim to control future outcomes through present actions.
本文探讨了使用CRISPR - Cas9进行基因编辑所带来的生存风险和优生学风险。它提出了认识论和现象学问题，涉及CRISPR技术对人类存在极限的暗示。通过阐明我们“过去的自我”与“现在的自我”之间的矛盾关系，它思考了我们个人和集体塑造未来努力的脆弱性。为此，本文概述了现代主体面临的生存困境、优生学历史和健康意识形态、对人类知识极限的思考，以及对隐喻文化作用的阐释。它论证了人类变异对个人和社区的益处，并呼吁以谦逊和克制的态度来指导人道技术而非旨在通过当前行动控制未来结果的基因操纵技术的开发与应用。
