Department of Public Health, School of Medicine, Dezful University of Medical Sciences, Dezful, IR.
Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, IR.
Ann Glob Health. 2020 Feb 3;86(1):11. doi: 10.5334/aogh.2449.
Vaccination is the most remarkable intervention in public health and is an effective strategy in controlling infectious diseases among infants.
The aim of this study was to compare the adverse events of Pentavalent vaccine and DPT vaccine in two- to six-month-old infants in Iran.
This is an analytical cross-sectional study in which healthy infants aged two to six months, having received DPT vaccine in 2013 and Pentavalent vaccine in 2015, were studied for any experienced adverse events related to these vaccines. Percentage, mean, standard deviation and chi-square tests were used to describe and analyze the data (p < 0.05).
The results showed that 10,464 and 17,561 adverse events, which were associated with DPT vaccine and Pentavalent vaccine respectively, were recorded in the infants who received these vaccines throughout Iran. Mazandaran, Qazvin and Golestan provinces reported the highest number of adverse events, respectively (15.74%, 11.25%, and 9.12%). Moreover, Pentavalent vaccine seemed to have more recorded adverse events compared to DPT, high fever had the highest record rate for DPT vaccine (47.4%) and mild localized complications was the highest for Pentavalent vaccines (31.68%). There was a significant relationship between the kind of vaccine and the type of reaction, adverse event categorization and the country that produced the vaccine (p < 0.05).
Severe localized adverse events including high fever, vomiting, diarrhea and restlessness seemed to be less in Pentavalent vaccine compared to DPT vaccine. Therefore, substituting Pentavalent vaccine for DPT vaccine in infants seems to reduce the adverse events among them.
疫苗接种是公共卫生领域最显著的干预措施，也是控制婴幼儿传染病的有效策略。
本研究旨在比较伊朗 2 至 6 个月大婴儿接种五联疫苗和百白破疫苗的不良反应。
这是一项分析性的横断面研究，研究对象为 2013 年接种百白破疫苗和 2015 年接种五联疫苗的 2 至 6 个月大健康婴儿，研究他们是否有与这些疫苗相关的任何不良反应。使用百分比、平均值、标准差和卡方检验来描述和分析数据（p < 0.05）。
结果显示，在伊朗接受这些疫苗的婴儿中，分别记录了 10464 例和 17561 例与 DPT 疫苗和五联疫苗相关的不良反应。马赞达兰、卡泽伦和戈勒斯坦省报告的不良反应数量最多（分别为 15.74%、11.25%和 9.12%）。此外，与 DPT 相比，五联疫苗似乎记录了更多的不良反应，高热是 DPT 疫苗记录率最高的不良反应（47.4%），而五联疫苗记录的轻度局部并发症发生率最高（31.68%）。疫苗种类与反应类型、不良反应分类和疫苗生产国之间存在显著关系（p < 0.05）。
与 DPT 疫苗相比，五联疫苗似乎较少出现严重的局部不良反应，包括高热、呕吐、腹泻和烦躁不安。因此，用五联疫苗替代 DPT 疫苗接种婴儿可能会减少他们的不良反应。
