Atchimnaidu Siriki, Thelu Hari Veera Prasad, Perumal Devanathan, Harikrishnan Kaloor S, Varghese Reji
School of Chemistry, Indian Institute of Science Education and Research (IISER) Thiruvananthapuram, Thiruvananthapuram, India.
Front Chem. 2020 Jan 28;8:2. doi: 10.3389/fchem.2020.00002. eCollection 2020.
Design and synthesis of physically (non-covalently) cross-linked nanoparticles through host-guest interaction between β-CD and adamantane is reported. Specific molecular recognition between β-CD functionalized branched DNA nanostructures (host) and a star-shaped adamantyl-terminated 8-arm poly(ethylene glycol) polymer (guest) is explored for the design of the nanoparticles. The most remarkable structural features of DNA nanoparticles include their excellent biocompatibility and the possibility of various non-covalent interactions with both hydrophobic and hydrophilic organic molecules. Potential of DNA nanoparticles for the rapid and efficient capture of various micropollutants typically present in water including carcinogens (hydrophobic micropollutants), organic dyes (hydrophilic), and pharmaceutical molecules (hydrophilic) is also demonstrated. The capture of micropollutants by DNA nanoparticles is attributed to the various non-covalent interactions between DNA nanoparticles and the micropollutants. Our results clearly suggest that DNA based nanomaterials would be an ideal candidate for the capturing and removal of both hydrophilic and hydrophobic micropollutants typically present in water.
报道了通过β-环糊精（β-CD）与金刚烷之间的主客体相互作用设计和合成物理（非共价）交联纳米颗粒。探索了β-CD功能化的支链DNA纳米结构（主体）与星形金刚烷基封端的八臂聚乙二醇聚合物（客体）之间的特异性分子识别，以设计纳米颗粒。DNA纳米颗粒最显著的结构特征包括其优异的生物相容性以及与疏水性和亲水性有机分子发生各种非共价相互作用的可能性。还证明了DNA纳米颗粒能够快速有效地捕获水中通常存在的各种微污染物，包括致癌物（疏水性微污染物）、有机染料（亲水性）和药物分子（亲水性）。DNA纳米颗粒对微污染物的捕获归因于DNA纳米颗粒与微污染物之间的各种非共价相互作用。我们的结果清楚地表明，基于DNA的纳米材料将是捕获和去除水中通常存在的亲水性和疏水性微污染物的理想候选材料。
