National Center for Nanoscience and Technology, Beijing 100190, PR China.
Small. 2013 Jul 22;9(14):2382-92. doi: 10.1002/smll.201300824. Epub 2013 Jun 17.
DNA-based nanomachines are self-assembled DNA superstructures that harness chemical free energy to perform mechanical work. The development of DNA machines has benefited greatly from the achievements in both structural and dynamic DNA nanotechnology. In this review, the configurations of DNA machines, fuel systems, and operations are discussed to outline the evolving paths of DNA machines. The focus is on the smart mechanical behavior of DNA machines, from the standpoint of upgrading the complexity of DNA nanostructures, cooperative activation of multimachinary systems, and the establishment of a network of the mechanical states. In the end, the challenges are highlighted and possible solutions are proposed to push forward smart DNA nanomachines, with the goal of creating biomimicking systems. Insights are also provided into the potential applications of the DNA machines with designable intelligence.
基于 DNA 的纳米机器是自组装的 DNA 超结构，利用化学自由能来进行机械功。DNA 机器的发展得益于结构和动态 DNA 纳米技术的成就。在这篇综述中，讨论了 DNA 机器的结构、燃料系统和操作，以概述 DNA 机器的发展路径。重点是从升级 DNA 纳米结构的复杂性、协同激活多机器系统以及建立机械状态网络的角度来看待 DNA 机器的智能机械行为。最后，强调了挑战，并提出了可能的解决方案，以推动智能 DNA 纳米机器的发展，目标是创建仿生系统。还提供了有关具有可设计智能的 DNA 机器的潜在应用的见解。
