氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描（FDG-PET/CT）在评估血压与心肌代谢摄取之间相关性中的作用
Role of FDG-PET/CT in Assessing the Correlation Between Blood Pressure and Myocardial Metabolic Uptake.
作者信息
Rojulpote Chaitanya, Mehdizadeh Seraj Siavash, Zirakchian Zadeh Mahdi, Yadav Divya, Raynor William Y, Kothekar Esha, Al-Zaghal Abdullah, Werner Thomas J, Gerke Oke, Høilund-Carlsen Poul Flemming, Alavi Abass
机构信息
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, United States.
出版信息
Asia Ocean J Nucl Med Biol. 2020 Winter;8(1):36-45. doi: 10.22038/aojnmb.2019.41530.1282.
OBJECTIVES
We aimed to assess the association between blood pressure and LV myocardial uptake of FDG, hypothesizing that subjects with raised blood pressure would have higher FDG uptake.
METHODS
We analyzed 86 healthy controls who underwent PET/CT imaging 180 minutes following FDG (4 MBq/Kg) administration. LV myocardial analysis was performed on axial sections using standard operator guided computer software (OsiriX MD). The average LV myocardial SUV (MSUV) was calculated for each subject. Subjects were assessed according to the 2017 ACC/AHA guidelines for high blood pressure in adults. Mean arterial blood pressure (MABP) was calculated for each patient. Regression models were employed for statistical analysis.
RESULTS
The association of MSUV was more pronounced with DP (r=0.32, p=0.003) than SP (r=0.28, p=0.010); MABP was comparable (r=0.33, p=0.002). Correlations of MSUV with categorized BPs were: normal SP (r=0.27, p=0.010), elevated SP (r=0.28, p=0.009), stage 1 SP (r=0.27, p=0.010), stage 2 SP (r=0.28, p=0.008); normal DP (r=0.33, p=0.001), stage 1 DP (r=0.34, p=0.001), stage 2 DP (r=0.35, p=0.001). Multivariate analysis demonstrated DP (p=0.006), MABP (p=0.007), and SP (0.026).
CONCLUSION
LV myocardial FDG uptake was higher in subjects with elevated blood pressure and correlated positively with SBP and in particular DBP and MABP.
目的
我们旨在评估血压与左心室心肌对氟代脱氧葡萄糖（FDG）摄取之间的关联，假设血压升高的受试者FDG摄取会更高。
方法
我们分析了86名健康对照者，他们在注射FDG（4MBq/千克）后180分钟接受了PET/CT成像。使用标准的操作员引导计算机软件（OsiriX MD）在轴位图像上对左心室心肌进行分析。计算每个受试者的左心室心肌平均标准摄取值（MSUV）。根据2017年美国心脏病学会/美国心脏协会成人高血压指南对受试者进行评估。计算每位患者的平均动脉血压（MABP）。采用回归模型进行统计分析。
结果
MSUV与舒张压（DP）的关联（r=0.32，p=0.003）比与收缩压（SP）的关联（r=0.28，p=0.010）更显著；MABP的情况与之相当（r=0.33，p=0.002）。MSUV与分类血压的相关性如下：正常SP（r=0.27，p=0.010）、升高的SP（r=0.28，p=0.009）、1期SP（r=0.27，p=0.010）、2期SP（r=0.28，p=0.008）；正常DP（r=0.33，p=0.001）、1期DP（r=0.34，p=0.001）、2期DP（r=0.35，p=0.001）。多变量分析显示DP（p=0.006）、MABP（p=0.007）和SP（0.026）。
结论
血压升高的受试者左心室心肌FDG摄取更高，且与收缩压呈正相关，尤其是与舒张压和平均动脉血压呈正相关。
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