Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.
Phys Chem Chem Phys. 2020 Feb 26;22(8):4313-4325. doi: 10.1039/c9cp05815j.
This perspective highlights recent advances in super-resolution, mid-infrared imaging and spectroscopy. It provides an overview of the different near field microscopy techniques developed to address the problem of chemically imaging specimens in the mid-infrared "fingerprint" region of the spectrum with high spatial resolution. We focus on a recently developed far-field optical technique, called infrared photothermal heterodyne imaging (IR-PHI), and discusses the technique in detail. Its practical implementation in terms of equipment used, optical geometries employed, and underlying contrast mechanism are described. Milestones where IR-PHI has led to notable advances in bioscience and materials science are summarized. The perspective concludes with a future outlook for robust and readily accessible high spatial resolution, mid-infrared imaging and spectroscopy techniques.
本文重点介绍了超分辨率、中红外成象和光谱学的最新进展。概述了为解决在中红外“指纹”谱区用高空间分辨率对样品进行化学成象这一问题而发展起来的各种近场显微镜技术。我们集中讨论了一种新的远场光学技术，称为红外光热外差成象（IR-PHI），并详细讨论了该技术。文中描述了其在设备使用、光学几何结构和潜在对比机制方面的实际应用。总结了 IR-PHI 在生物科学和材料科学方面取得显著进展的重要阶段。本文最后展望了具有稳健、易于获取的高空间分辨率的中红外成象和光谱学技术的未来。
