高水平的循环 microRNA-142 与急性心肌梗死和降低的生存率相关。

High level of circulating microRNA-142 is associated with acute myocardial infarction and reduced survival.

机构信息

Department of Cardiology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, Yangpu District, China.

Department of Internal Medicine, Chinese People's Liberation Army Air Force, Huizhou, Huizhou station hospital, Huizhou, 516259, Guangdong, China.

出版信息

Ir J Med Sci. 2020 Aug;189(3):933-937. doi: 10.1007/s11845-020-02196-5. Epub 2020 Feb 17.

DOI:10.1007/s11845-020-02196-5

PMID:32064546

Abstract

BACKGROUND

Recent study reported that microRNA-142 (miR-142) were up-regulated in the atherosclerotic plaques, which may be responsible for pathogenesis of atherosclerosis. However, whether it associates with presence of acute myocardial infarction (AMI), and its prognostic value is still unknown. We, therefore, investigated the association between miR-142 expression and presence of AMI, and its prognostic value in AMI patients.

METHODS

We included 300 AMI patients and 100 subjects as the control group. MiR-142 content was detected by quantitative real-time polymerase chain reaction. MiR-142 level was identified in all subjects. The multivariate logistic regression analysis were performed to evaluate the risk factors of AMI. The Kaplan-Meier analysis was performed to determine the major adverse cardiovascular and cerebrovascular events (MACCE)-free survival.

RESULTS

AMI group had significantly higher miR-142 level in comparison to the controls [4.10 (2.03-7.43) vs. 1.92 (0.91-2.91), p < 0.001], moreover, miR-142 content was significantly associated with cardiac troponin I (cTnI) level (r = 0.707, p < 0.001). The MACCE-free survival was significantly lower over 24-month for patients in miR-142 high expression group (72.4% ± 5.6% vs. 76.4% ± 5.1%) (p = 0.022). After adjusting for the traditional risk factors, the odds ratios of miR-142 was 14.74 (95% CI, 2.15-101.24). The multivariate logistic regression analysis revealed that miR-142 level significantly associated with presence of AMI (p < 0.001).

CONCLUSION

The serum level of miR-142 was increased in AMI patients when compared with health population. Furthermore, use of this marker may allow a certain predictor of the MACCE in AMI patients.

摘要

背景

最近的研究报告称，微小 RNA-142（miR-142）在动脉粥样硬化斑块中上调，这可能与动脉粥样硬化的发病机制有关。然而，它是否与急性心肌梗死（AMI）的存在有关，以及它在 AMI 患者中的预后价值尚不清楚。因此，我们研究了 miR-142 表达与 AMI 存在之间的关系及其在 AMI 患者中的预后价值。

方法

我们纳入了 300 例 AMI 患者和 100 例作为对照组的受试者。通过实时定量聚合酶链反应检测 miR-142 的含量。对所有受试者进行 miR-142 水平检测。采用多变量逻辑回归分析评估 AMI 的危险因素。采用 Kaplan-Meier 分析确定主要不良心血管和脑血管事件（MACCE）无事件生存率。

结果

与对照组相比，AMI 组的 miR-142 水平显著升高[4.10（2.03-7.43）比 1.92（0.91-2.91），p<0.001]，此外，miR-142 含量与心肌肌钙蛋白 I（cTnI）水平显著相关（r=0.707，p<0.001）。在 24 个月时，miR-142 高表达组的 MACCE 无事件生存率明显较低（72.4%±5.6%比 76.4%±5.1%）（p=0.022）。在调整了传统危险因素后，miR-142 的比值比为 14.74（95%可信区间，2.15-101.24）。多变量逻辑回归分析显示，miR-142 水平与 AMI 的存在显著相关（p<0.001）。