血清 microRNA-665 表达与急性心肌梗死患者冠状动脉狭窄程度及主要不良心血管事件的相关性分析。
Correlation analysis between the expression of serum microRNA-665 and the degree of coronary artery stenosis and major adverse cardiovascular events in patients with acute myocardial infarction.
机构信息
Department of Pharmacy, Zhangjiakou First Hospital, No. 6, Jianguo Road, Qiaodong District, Zhangjiakou, 075000, China.
Department of Cardiovascular, Shijiazhuang City Luancheng People's Hospital, Shijiazhuang, 051430, China.
出版信息
J Cardiothorac Surg. 2024 Sep 23;19(1):543. doi: 10.1186/s13019-024-02998-z.
BACKGROUND
The purpose of this study was to explore the expression of miR-665 in acute myocardial infarction (AMI) and evaluate its significance in the diagnosis and prognosis of AMI.
METHODS
100 patients with AMI were selected as the study group and 80 healthy subjects were chosen as the control group. The levels of miR-665 were detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) in the two groups. The diagnostic value of miR-665 expression level in AMI was analyzed by the receiver operator characteristic (ROC) curve. Kaplan-Meier curve and Cox regression were used to evaluate the predictive value of miR-665 for major adverse cardiovascular events (MACEs) in patients with AMI within 30 days after percutaneous coronary intervention (PCI).
RESULTS
The serum miR-665 level of the study group was significantly lower than that of the control group. The level of miR-665 was significantly correlated with clinical indicators of patients with AMI. ROC curve showed that miR-665 has a high diagnostic value for AMI. Survival analysis showed that Gensini score and miR-665 were independent risk factors for the occurrence of MACEs within 30 days after PCI in patients with AMI.
CONCLUSIONS
Abnormal decrease of serum miR-665 expression level in patients with AMI may increase the risk of MACEs occurrence after PCI.
背景
本研究旨在探讨 miR-665 在急性心肌梗死（AMI）中的表达，并评估其在 AMI 诊断和预后中的意义。
方法
选择 100 例 AMI 患者作为研究组，80 例健康受试者作为对照组。采用逆转录定量聚合酶链反应（RT-qPCR）检测两组患者 miR-665 水平。通过受试者工作特征（ROC）曲线分析 miR-665 表达水平对 AMI 的诊断价值。采用 Kaplan-Meier 曲线和 Cox 回归分析评估 miR-665 对经皮冠状动脉介入治疗（PCI）后 30 天内 AMI 患者主要不良心血管事件（MACEs）的预测价值。
结果
研究组血清 miR-665 水平明显低于对照组。miR-665 水平与 AMI 患者的临床指标显著相关。ROC 曲线表明，miR-665 对 AMI 具有较高的诊断价值。生存分析显示，Gensini 评分和 miR-665 是 AMI 患者 PCI 后 30 天内发生 MACEs 的独立危险因素。
结论
AMI 患者血清 miR-665 表达水平异常降低可能增加 PCI 后 MACEs 发生的风险。
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