The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada.
Department of Psychiatry, University of Calgary, Alberta, Canada.
Can J Psychiatry. 2020 Aug;65(8):521-530. doi: 10.1177/0706743720904820. Epub 2020 Feb 17.
To identify and assess pharmacogenetic testing options relevant to psychiatry in Canada.
Searches of published literature, websites, and Standard Council of Canada's Laboratory Directory were conducted to identify pharmacogenetic tests available in Canada. Identified tests were assessed on 8 key questions related to analytical validity, accessibility, test ordering, delivery of test results, turnaround time, cost, clinical trial evidence, and gene/allele content.
A total of 13 pharmacogenetic tests relevant to psychiatry in Canada were identified. All tests were highly accessible, and most were conducted in accredited laboratories. Both direct-to-consumer and clinician-gated testing were identified, with turnaround times and cost ranging from 2 to 40 days and CAD$199 to CAD$2310, respectively. Two tests were supported by randomized controlled trials. All tests met minimum gene and allele panel recommendations for psychiatry, but no 2 panels were identical. No test was unequivocally superior to all other tests.
Pharmacogenetic testing in Canada is readily available but highly variable in terms of ordering procedures, delivery of results, turnaround times, cost, and gene/allele content. As such, it is important for psychiatrists and other health-care providers to understand the differences between the available tests to ensure appropriate selection and implementation within their practice.
确定并评估加拿大精神病学相关的遗传药理学检测选项。
通过检索已发表的文献、网站以及加拿大标准协会的实验室名录，确定加拿大可用的遗传药理学检测方法。针对分析有效性、可及性、检测订购、检测结果传递、周转时间、成本、临床试验证据和基因/等位基因内容这 8 个关键问题，对所确定的检测方法进行评估。
共确定了 13 项加拿大精神病学相关的遗传药理学检测方法。所有检测均具有高度可及性，且大多数检测均在认可的实验室中进行。既鉴定了面向消费者的直接检测，也鉴定了由临床医生把关的检测，其周转时间和成本分别为 2 至 40 天和 CAD$199 至 CAD$2310。两项检测得到了随机对照试验的支持。所有检测均符合精神病学的最低基因和等位基因面板推荐标准，但没有两个面板是完全相同的。没有一种检测在所有方面都明显优于其他检测。
加拿大的遗传药理学检测方法广泛可用，但在订购程序、结果传递、周转时间、成本和基因/等位基因内容方面存在高度差异。因此，精神病医生和其他医疗保健提供者了解可用检测方法之间的差异非常重要，以确保在其实践中进行适当的选择和实施。
