Are Randomized Controlled Trials Necessary to Establish the Value of Implementing Pharmacogenomics in the Clinic?
作者信息
Huddart Rachel, Sangkuhl Katrin, Whirl-Carrillo Michelle, Klein Teri E
机构信息
Department of Biomedical Data Science, Stanford University, Stanford, California, USA.
Department of Medicine, Stanford University, Stanford, California, USA.
出版信息
Clin Pharmacol Ther. 2019 Aug;106(2):284-286. doi: 10.1002/cpt.1420. Epub 2019 Apr 12.
Abstract
摘要
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Are Randomized Controlled Trials Necessary to Establish the Value of Implementing Pharmacogenomics in the Clinic?在临床实践中，确定实施药物基因组学的价值是否需要随机对照试验？
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本文引用的文献
1
When will clinical trials finally reflect diversity?临床试验最终何时才能反映出多样性？
Nature. 2018 May;557(7704):157-159. doi: 10.1038/d41586-018-05049-5.
2
Pharmacogenomic substudies of randomized controlled trials: consideration of safety outcomes.随机对照试验的药物基因组学子研究：对安全性结果的考量
Ther Adv Drug Saf. 2014 Apr;5(2):62-6. doi: 10.1177/2042098613520030.
3
HLA diversity in the 1000 genomes dataset.千人基因组数据集中的人类白细胞抗原（HLA）多样性。
PLoS One. 2014 Jul 2;9(7):e97282. doi: 10.1371/journal.pone.0097282. eCollection 2014.
4
Promises and challenges of pharmacogenetics: an overview of study design, methodological and statistical issues.药物遗传学的前景与挑战：研究设计、方法学及统计学问题综述
JRSM Cardiovasc Dis. 2012 Apr 5;1(1):cvd.2012.012001. doi: 10.1258/cvd.2012.012001.
5
Pharmacogenetic tests: the need for a level playing field.药物遗传学检测：需要公平竞争环境。
Nat Rev Drug Discov. 2013 Jan;12(1):3-4. doi: 10.1038/nrd3921.
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