低 25-羟维生素 D 水平在早产儿晚发性败血症中的作用。
The Role of Low 25-Hydroxyvitamin D Levels in Preterm Infants with Late-Onset Sepsis.
机构信息
Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Uludag University, Bursa, Turkey.
Faculty of Medicine, Department of Pediatrics, Division of Infectious Diseases, Uludag University, Bursa, Turkey.
出版信息
Fetal Pediatr Pathol. 2021 Dec;40(6):571-580. doi: 10.1080/15513815.2020.1725941. Epub 2020 Feb 17.
We investigated the association between low 25-hydroxyvitamin D (25-OHD) levels and late-onset sepsis (LOS) in preterm infants (<37 weeks). Infants with culture-proven LOS were the study group, infants without LOS were the controls. 25-OHD levels were compared between these groups. Low vitamin D was defined as 25-OHD ≤15 ng/ml. Maternal 25-OHD levels were compared to their infant's level. 108 infants were included. The study group was significantly younger (p = 0.02) with significantly lower 25-OHD levels (p < 0.001). Multivariable logistic regression analyses revealed that infants with low 25-OHD levels were 7.159 (95%CI: 1.402-36.553, p = 0.018) times more likely to develop LOS. A positive correlation was detected between maternal and neonatal 25-OHD levels for both study and control groups (r = 0.425, p = 0.009; r = 0.739, p < 0.001, respectively). Low 25-OHD levels are associated with an increased risk of developing LOS development in preterm infants.
我们研究了早产儿（<37 周）中低 25-羟维生素 D（25-OHD）水平与晚发性败血症（LOS）之间的关联。患有培养阳性 LOS 的婴儿为研究组，无 LOS 的婴儿为对照组。比较了这些组之间的 25-OHD 水平。低维生素 D 定义为 25-OHD≤15ng/ml。比较了产妇的 25-OHD 水平与其婴儿的水平。共纳入 108 名婴儿。研究组明显更年轻（p=0.02），25-OHD 水平明显更低（p<0.001）。多变量逻辑回归分析表明，25-OHD 水平低的婴儿发生 LOS 的可能性高 7.159 倍（95%CI：1.402-36.553，p=0.018）。研究组和对照组的母婴 25-OHD 水平均呈正相关（r=0.425，p=0.009；r=0.739，p<0.001）。低 25-OHD 水平与早产儿 LOS 发展的风险增加有关。
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