母婴维生素D缺乏：早产儿坏死性小肠结肠炎的一个新危险因素？
Maternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?
作者信息
Cetinkaya M, Erener-Ercan T, Kalayci-Oral T, Babayiğit A, Cebeci B, Semerci S Y, Buyukkale G
机构信息
Department of Neonatology, Kanuni Sultan Suleyman Teaching and Research Hospital, Istanbul, Turkey.
Faculty of Medicine, Department of Neonatology, Maltepe University, Istanbul, Turkey.
出版信息
J Perinatol. 2017 Jun;37(6):673-678. doi: 10.1038/jp.2017.18. Epub 2017 Mar 23.
OBJECTIVE
The objective of the study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of necrotizing enterocolitis (NEC).
STUDY DESIGN
One hundred and forty-five preterm infants ⩽36 weeks of gestation were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.
RESULTS
Of the 145 enrolled patients, 26 (18%) developed NEC. Maternal/neonatal 25-OHD levels in the NEC group were significantly lower than those of the no-NEC group (P=0.001 and 0.004, respectively). In univariate logistic regression analysis, both maternal/neonatal vitamin D levels were a significant predictor of NEC (odds ratio (OR): 0.92 and 0.89; P<0.001 and P<0.005, respectively). However, multivariate logistic regression analysis revealed that only maternal vitamin D level was a significant predictor of NEC (OR: 0.86, P<0.0009).
CONCLUSION
This is the first study to propose a possible association between maternal/neonatal 25-OHD levels and subsequent development of NEC in preterm infants.
目的
本研究旨在调查母体/新生儿25-羟基维生素D（25-OHD）水平与坏死性小肠结肠炎（NEC）发生之间的可能关联。
研究设计
纳入145例孕周≤36周的早产儿。在新生儿重症监护病房入院时采集母体/新生儿血样，测定其中25-OHD水平。
结果
145例纳入患者中，26例（18%）发生了NEC。NEC组的母体/新生儿25-OHD水平显著低于无NEC组（分别为P = 0.001和0.004）。在单因素逻辑回归分析中，母体/新生儿维生素D水平均是NEC的显著预测因素（优势比（OR）：分别为0.92和0.89；P < 0.001和P < 0.005）。然而，多因素逻辑回归分析显示，只有母体维生素D水平是NEC的显著预测因素（OR：0.86，P < 0.0009）。
结论
本研究首次提出母体/新生儿25-OHD水平与早产儿随后发生NEC之间可能存在关联。
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