Bjørklund Geir, Semenova Yuliya, Pivina Lyudmila, Dadar Maryam, Rahman Md Mostafizur, Aaseth Jan, Chirumbolo Salvatore
Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.
Semey Medical University, Semey, Kazakhstan.
Arch Toxicol. 2020 May;94(5):1551-1560. doi: 10.1007/s00204-020-02676-8. Epub 2020 Feb 17.
Uranium (U) has no known essential biological functions. Furthermore, it is well known for its toxicity, radioactivity, and carcinogenic potency. Impacts on human health due to U exposure have been studied extensively by many researchers. Chronic exposure to low-level U isotopes (radionuclides) may be interlinked with cancer etiology and at high exposure levels, also kidney disease. Other important issues covered U and fertilizers, and also U in soils or human tissues as an easily measurable indicator element in a pathophysiological examination. Furthermore, phosphate fertilization is known as the important source of contamination with U in the agricultural land, mainly due to contamination in the phosphate rock applied for fertilizer manufacture. Therefore, long-term usage of U-bearing fertilizers can substantially increase the concentration of U in fertilized soils. It should also be noted that U is an active redox catalyst for the reaction between DNA and HO. This review is aimed to highlight a series on various hydro-geochemical aspects in different water sources and focused on the comparison of different U contents in the drinking water sources and presentation of data in relation to health issues.
铀(U)没有已知的基本生物学功能。此外,它以其毒性、放射性和致癌潜力而闻名。许多研究人员对铀暴露对人类健康的影响进行了广泛研究。长期接触低水平的铀同位素(放射性核素)可能与癌症病因有关,而在高暴露水平下,还与肾脏疾病有关。其他重要问题涉及铀与肥料,以及土壤或人体组织中的铀作为病理生理学检查中易于测量的指示元素。此外,磷肥被认为是农业土地中铀污染的重要来源,主要是由于用于肥料生产的磷矿石受到污染。因此,长期使用含铀肥料会大幅增加施肥土壤中铀的浓度。还应注意的是,铀是DNA与羟基自由基(HO)之间反应的活性氧化还原催化剂。本综述旨在突出不同水源中各种水文地球化学方面的一系列内容,并侧重于比较饮用水源中不同的铀含量以及呈现与健康问题相关的数据。