University of Wyoming, Laramie, WY, USA.
Boise State University, Boise, ID, USA.
J Chem Ecol. 2020 Feb;46(2):198-205. doi: 10.1007/s10886-020-01146-w. Epub 2020 Feb 17.
In this paper, compartmental pharmacokinetic models are built to predict the concentration of toxic phytochemical in the gastrointestinal tract and blood following oral intake by an individual vertebrate herbivore. The existing single and multiple dose pharmacokinetic models are extended by inclusion of impulsive differential equations which account for an excretion factor whereby unchanged toxins are excreted in the feces due to gastrointestinal mobility. An index α is defined to measure the fraction of bioavailability attributed to the excretion factor of gastrointestinal motility. Sensitivity analysis was conducted and suggests, for any toxin, the bioavailability index α depends mostly on absorption rate of toxin from gastrointestinal tract into the blood, frequency of elimination due to gastrointestinal motility, and the frequency of toxin intake, under the model assumptions.
在本文中，构建了房室药代动力学模型，以预测脊椎动物草食动物口服摄入有毒植物化学物质后在胃肠道和血液中的浓度。通过纳入冲动微分方程，将现有的单剂量和多剂量药代动力学模型进行了扩展，该方程考虑了一个排泄因子，由于胃肠道的移动性，未改变的毒素会随粪便排出。定义了一个指数α，以衡量归因于胃肠道蠕动排泄因子的生物利用度分数。敏感性分析表明，在模型假设下，对于任何毒素，生物利用度指数α主要取决于毒素从胃肠道吸收到血液中的吸收速率、由于胃肠道蠕动导致的消除频率以及毒素摄入的频率。
