McDade Thomas W, Borja Judith B, Lee Nanette, Aquino Celine T, Barrett Tyler, Adair Linda S, Kuzawa Christopher W
Department of Anthropology, Northwestern University, Evanston, IL, USA.
Institute for Policy Research, Northwestern University, Evanston, IL, USA.
Biodemography Soc Biol. 2020 Jan-Mar;65(1):88-96. doi: 10.1080/19485565.2019.1597623.
Inflammation is associated with increased risk for chronic degenerative diseases, as well as age-related functional declines across many systems and tissues. Current understandings of inflammation, aging, and human health are based on studies conducted almost exclusively in high-income nations that rely primarily on baseline measures of chronic inflammation. This analysis investigates the inflammatory response to vaccination as a predictor of cardiovascular disease (CVD) among older women in the Philippines, a lower-middle income nation with rising rates of overweight/obesity and relatively high burdens of infectious disease. Concentrations of C-reactive protein (CRP) were measured at baseline and 72 h following influenza vaccination in 530 women (mean age = 55.2 years). Ankle-brachial index (ABI) - an indicator of peripheral arterial disease and broader CVD risk - was measured approximately three years later. The magnitude of CRP response to vaccination was positively associated with ABI, indicating that a larger inflammatory response predicts lower CVD risk. Baseline CRP was negatively associated with CRP response to vaccination, and was not associated with ABI independently of CRP response. These results suggest that research across ecological settings, and with more dynamic measures of inflammatory response and regulation, may yield important insights into the associations among inflammation, aging, and disease.
炎症与慢性退行性疾病风险增加相关，也与许多系统和组织中与年龄相关的功能衰退有关。目前对炎症、衰老和人类健康的理解几乎完全基于在高收入国家进行的研究，这些研究主要依赖于慢性炎症的基线测量。本分析调查了菲律宾老年女性接种疫苗后的炎症反应，以此作为心血管疾病（CVD）的预测指标。菲律宾是一个中低收入国家，超重/肥胖率不断上升，传染病负担相对较高。对530名女性（平均年龄 = 55.2岁）在流感疫苗接种前和接种后72小时测量了C反应蛋白（CRP）浓度。大约三年后测量了踝臂指数（ABI），这是外周动脉疾病和更广泛的CVD风险的一个指标。CRP对疫苗接种反应的幅度与ABI呈正相关，表明更大的炎症反应预示着更低的CVD风险。基线CRP与CRP对疫苗接种的反应呈负相关，且独立于CRP反应与ABI无关。这些结果表明，跨生态环境进行研究，并采用更动态的炎症反应和调节测量方法，可能会对炎症、衰老和疾病之间的关联产生重要见解。
