Integrative analyses identify a DNA damage repair gene signature for prognosis prediction in lower grade gliomas.

The DNA damage repair (DDR) pathways play important roles for regulating cancer progression and therapeutic response. mutations, well-known prognosis biomarkers for glioma, lead to hypermethylation of tumor cells and affect genes' expression. Whether mutations affect glioma prognosis through influencing the expression of DDR genes remains unclear. A total of 272 DDR genes were selected for differential expression and survival analysis. The identified genes were then utilized to construct the prognosis predicting model. , , and were found differential expressed between mutations carriers and wild-type carriers, and were associated with survival of low grade glioma (LGG) patients. The predicting algorithm can predicts the prognosis of LGG patients. mutations may affect LGG prognosis through regulation of DDR pathways.