[Deamination of indolalkylamines in hyperthermia].

The experiments on dogs subjected to the outward overheating allow concluding that the quantities of deaminated serotonin in mitochondrial fractions of the brain stem, heart muscles and liver increase twice as compared with the normal levels. Particularly, in the liver the value of Km of this process is equal to 1.6 x 10(-3) M, while without the overheating it is equal to 3.6 x 10(-3) M. Overheating makes the process of tryptamine deamination in mitochondrial fractions of the heart and liver more intensive. However, overheating causes a higher increase of the monoaminooxidase activity with respect to serotonin than with respect to other substrates.