Raĭgorodskaia D I, Gorkin V Z, Fedotova I B, Semiokhina A F
Vopr Med Khim. 1991 Mar-Apr;37(2):46-8.
Catalytic properties of mitochondrial monoamine oxidases (MAO) were studied in brain, heart, liver and kidney of rats of Krushinskii-Molodkina strain with inherited audiogenic epilepsia. In brain of these rats a. 2.5-fold decrease of Vmax of serotonin (MAO-A substrate) deamination has been found. During audiogenic epileptiformic attack 2.5-5-fold decrease of Vmax of serotonin deamination in brain and liver and also decrease of benzylamine (MAO-B substrate) oxidation in brain were found. Simultaneously oxidation of glucosamine and gamma-aminobutyric acid was markedly increased (up to 5-fold and more) in brain. The data obtained showed that qualitative transformation occurred in catalytic properties of MAO which may be an important pathogenic factor in the development of epileptiformic attack.
研究了遗传性听源性癫痫的克鲁申斯基-莫洛迪纳品系大鼠脑、心、肝和肾中线粒体单胺氧化酶（MAO）的催化特性。在这些大鼠的脑中，已发现血清素（MAO-A底物）脱氨基作用的Vmax降低了2.5倍。在听源性癫痫样发作期间，发现脑中血清素脱氨基作用的Vmax降低了2.5至5倍，肝中也降低，同时脑中苄胺（MAO-B底物）氧化作用降低。同时，脑中氨基葡萄糖和γ-氨基丁酸的氧化作用显著增加（高达5倍及以上）。所获得的数据表明，MAO的催化特性发生了质的转变，这可能是癫痫样发作发展中的一个重要致病因素。
