Department of Medical Radiation Sciences, Curtin University, Perth, WA, Australia.
Multi-Modality Medical Imaging (M3I) Group, Technical Medical Centre, University of Twente, Enschede, The Netherlands.
Artif Organs. 2020 Aug;44(8):818-826. doi: 10.1111/aor.13670. Epub 2020 Mar 25.
Having physiological correct flow waveforms is a key feature for experimental studies of blood flow, especially in the process of developing and testing a new medical device such as stent, mechanical heart valve, or any implantable medical device that involves circulation of blood through the device. It is also a critical part of a perfusion system for cardiopulmonary bypass and extracorporeal membrane oxygenation procedures. This study investigated the feasibility of a novel roller pump for use in experimental flow phantoms. Flow rates of carotid flow profile measured directly with the ultrasonic flow meter matched well with the reference flow rates programmed into the machine with similarity index of 0.97 and measured versus programmed flow rates at specific time-points of peak systolic velocity (PSV): 0.894 vs 0.880, end systolic velocity (ESV): 0.333 vs 0.319, and peak diastolic velocity (PDV): 0.514 vs 0.520 L/min. Flow rates derived from video analysis of the pump motion for carotid, suprarenal, and infrarenal flows also matched well with references with similarity indices of 0.99, 0.99, and 0.96, respectively. Measured flow rates (mean/standard deviation) at PSV, ESV, and PDV time-points for carotid: 0.883/0.016 vs 0.880, 0.342/0.007 vs 0.319, and 0.485/0.009 vs 0.520; suprarenal: 3.497/0.014 vs 3.500, 0.004/0.003 vs 0, and 1.656/0.073 vs 1.453; infrarenal: 4.179/0.024 vs 4.250, -1.147/0.015 vs -1.213, and 0.339/0.017 vs 0.391 L/min, respectively. The novel roller pump is suitable for benchtop testing of physiological flow.
具有生理正确的流量波形是血流实验研究的关键特征，特别是在开发和测试新的医疗器械（如支架、机械心脏瓣膜或任何涉及血液通过设备循环的可植入医疗器械）的过程中。它也是心肺旁路和体外膜氧合程序中的灌注系统的关键部分。本研究调查了一种新型滚柱泵在实验性流量模拟中的可行性。通过超声流量计直接测量的颈动脉流量曲线与机器中编程的参考流量非常匹配，相似度指数为 0.97，并且在特定时间点的峰值收缩速度（PSV）、结束收缩速度（ESV）和峰值舒张速度（PDV）测量与编程的流量值相匹配：0.894 与 0.880、0.333 与 0.319、0.514 与 0.520 L/min。从颈动脉、肾上腺和肾下流量的泵运动视频分析中得出的流量也与参考值非常匹配，相似度指数分别为 0.99、0.99 和 0.96。颈动脉 PSV、ESV 和 PDV 时间点的测量流量（平均值/标准偏差）：0.883/0.016 与 0.880、0.342/0.007 与 0.319、0.485/0.009 与 0.520；肾上腺：3.497/0.014 与 3.500、0.004/0.003 与 0、1.656/0.073 与 1.453；肾下：4.179/0.024 与 4.250、-1.147/0.015 与-1.213、0.339/0.017 与 0.391 L/min。新型滚柱泵适用于生理流量的台式测试。
