The Third Affiliated Hospital of Southern Medical University; Zunyi Medical University, Guangzhou, Guangdong Province, China.
The First People's Hospital of Foshan, Foshan, Guangdong Province, China.
Aging (Albany NY). 2020 Feb 17;12(5):4660-4672. doi: 10.18632/aging.102811.
Renal fibrosis is an inevitable consequence of parenchymal scarring and is the common final pathway that mediates almost all progressive renal diseases. Adiponectin, a hormone produced by adipose tissue, possesses potent anti-insulin, anti-inflammatory, and anti-fibrotic properties. Reportedly, adiponectin serves as an important messenger that facilitates complex interactions between adipose tissue and other metabolically related organs. In recent years, a growing body of evidence supports adiponectin involvement in renal fibrosis. These studies provide a deeper understanding of the molecular mechanism of action of adiponectin in renal fibrosis and also offer a potential preventive and therapeutic target for renal fibrosis. In this review, the physiological role of adiponectin is briefly introduced, and then the mechanism of adiponectin-mediated renal fibrosis and the related signaling pathways are described. Finally, we summarize the findings regarding the clinical value of adiponectin in renal fibrotic diseases and prospected its application potential.
肾纤维化是实质瘢痕形成的必然结果，是介导几乎所有进行性肾脏疾病的共同终末途径。脂联素是脂肪组织产生的一种激素，具有强大的抗胰岛素、抗炎和抗纤维化特性。据报道，脂联素作为一种重要的信使，促进脂肪组织与其他代谢相关器官之间的复杂相互作用。近年来，越来越多的证据支持脂联素参与肾纤维化。这些研究加深了我们对脂联素在肾纤维化中的分子作用机制的理解，也为肾纤维化提供了一个有潜在预防和治疗作用的靶点。在这篇综述中，我们简要介绍了脂联素的生理作用，然后描述了脂联素介导的肾纤维化机制及其相关信号通路。最后，我们总结了脂联素在肾纤维化疾病中的临床价值，并展望了其应用潜力。
