The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Division of Diagnostic Imaging, Sheba Medical Center, Tel-Hashomer, Israel.
J Alzheimers Dis. 2020;74(2):649-658. doi: 10.3233/JAD-191294.
The efficacy of vitamin E in prevention of diabetes-related complications differs by Haptoglobin (Hp) genotype.
To examine the role of Hp genotype in the relationship of vitamin E intake with brain volume in cognitively normal elderly patients with type 2 diabetes.
Brain volumes for the superior, middle, and inferior frontal gyri and for the middle temporal gyrus were generated from structural T1 MRI in 181 study participants (Hp 1-1: n = 24, Hp 2-1: n = 77, Hp 2-2: n = 80). Daily vitamin E intake was assessed using the Food Frequency Questionnaire. Analyses of covariance, controlling for demographic and cardiovascular variables was used to evaluate whether the association of daily vitamin E intake with brain volume was modified by Hp genotype.
Average age was 70.8 (SD = 4.2) with 40% females, and mean Mini-Mental State Examination score of 28.17 (SD = 1.90). A significant interaction was found between vitamin E intake and Hp genotype in inferior frontal gyrus' volume; p = 0.0108. For every 1 microgram increase in vitamin E intake, the volume of the inferior frontal gyrus decreased by 0.955% for Hp 1-1 (p = 0.0348), increased by 0.429% for Hp 2-1 (p = 0.0457), and by 0.077% for Hp 2-2 (p = 0.6318). There were no significant interactions between vitamin E intake and Hp genotype for the middle (p = 0.6011) and superior (p = 0.2025) frontal gyri or for the middle temporal gyrus (p = 0.503).
The effect of dietary vitamin E on the brain may differ by Hp genotype. Studies examining the impact of vitamin E on brain-related outcomes should consider Hp genotype.
维生素 E 在预防糖尿病相关并发症方面的疗效因结合珠蛋白（Hp）基因型而异。
研究 Hp 基因型在维生素 E 摄入量与 2 型糖尿病认知正常老年患者脑容量之间关系中的作用。
在 181 名研究参与者中（Hp1-1：n=24、Hp2-1：n=77、Hp2-2：n=80），通过结构 T1 MRI 生成额上、中、下回和颞中回的脑容量。使用食物频率问卷评估每日维生素 E 摄入量。采用协方差分析，控制人口统计学和心血管变量，评估每日维生素 E 摄入量与脑容量的相关性是否受 Hp 基因型的影响。
平均年龄为 70.8（SD=4.2），女性占 40%，简易精神状态检查平均得分为 28.17（SD=1.90）。在额下回的体积中，发现维生素 E 摄入量与 Hp 基因型之间存在显著的交互作用；p=0.0108。对于 Hp1-1，每增加 1 微克的维生素 E 摄入量，额下回的体积减少 0.955%（p=0.0348）；对于 Hp2-1，增加 0.429%（p=0.0457）；对于 Hp2-2，增加 0.077%（p=0.6318）。对于中额（p=0.6011）和上额（p=0.2025）回以及颞中回（p=0.503），维生素 E 摄入量与 Hp 基因型之间没有显著的交互作用。
膳食维生素 E 对大脑的影响可能因 Hp 基因型而异。研究维生素 E 对与大脑相关的结果的影响时，应该考虑 Hp 基因型。
