Harvard Clinical Research Institute, 930 Commonwealth Avenue, Boston, MA 02467, USA.
Curr Diab Rep. 2012 Jun;12(3):274-9. doi: 10.1007/s11892-012-0265-8.
Diabetes mellitus (DM) carries an increased risk for cardiovascular complications. Haptoglobin (Hp) is an abundant plasma protein with an antioxidant function by virtue of its ability to block the oxidative activity of extracorpuscular hemoglobin. There exist two common functional alleles at the Hp genetic locus, denoted 1 and 2, with three Hp genotypes (Hp 1-1, 2-1, and 2-2). The Hp protein expressed in Hp 2-2 individuals is markedly inferior in protecting against hemoglobin-induced oxidative stress. Hp 2-2 DM individuals have been shown to be at increased risk for the development of diabetes complications, particularly diabetic cardiovascular disease (CVD). We review the biological mechanisms underlying the interaction between the Hp genotype and DM on CVD and the accumulating evidence in favor of Hp genotyping all individuals with DM and providing antioxidant vitamin E supplementation specifically to Hp 2-2 DM individuals to reduce their CVD morbidity and mortality.
糖尿病（DM）会增加心血管并发症的风险。触珠蛋白（Hp）是一种丰富的血浆蛋白，具有抗氧化功能，因为它能够阻止细胞外血红蛋白的氧化活性。Hp 遗传位点存在两个常见的功能等位基因，分别表示为 1 和 2，有三种 Hp 基因型（Hp 1-1、2-1 和 2-2）。在 Hp 2-2 个体中表达的 Hp 蛋白在保护血红蛋白诱导的氧化应激方面明显较差。已经表明，Hp 2-2DM 个体发生糖尿病并发症的风险增加，特别是糖尿病心血管疾病（CVD）。我们综述了 Hp 基因型与 DM 对 CVD 的相互作用的生物学机制，以及支持对所有 DM 个体进行 Hp 基因分型并专门向 Hp 2-2DM 个体补充抗氧化维生素 E 以降低其 CVD 发病率和死亡率的累积证据。
