Baykara Sema, Ocak Davut, Berk Şule Şirin, Köroğlu Sedat
Department of Psychiatry, Firat University Hospital, 23119 Elazig, Turkey.
Department of Psychiatry, School of Medicine, Fırat University, Elazig, Turkey.
Prim Care Companion CNS Disord. 2020 Feb 13;22(1):19m02541. doi: 10.4088/PCC.19m02541.
To identify the changes in QT dispersion (QTd), corrected QTd (QTcd), and P-wave dispersion (Pd) values with long-term alcohol abuse that could lead to severe ventricular arrhythmia, atrial fibrillation, and sudden death in alcohol use disorder (AUD) patients with excessive alcohol use.
This cross-sectional study included 48 individuals diagnosed with AUD based on DSM-5 criteria. Patients with a history of psychiatric diseases were not included. The control group comprised 48 individuals with no psychiatric diagnosis who did not abuse alcohol or other substances. Participants with body mass index > 24.9 kg/m² were excluded. Twelve-derivation electrocardiograms (ECG) were obtained from all participants.
The mean ± SD age was 44.35 ± 10.24 years in the AUD group and 40.90 ± 13.45 years in the control group. There was no significant difference between the groups based on age (P = .108). There was a significant difference between the groups based on smoking status (P = .000). The mean ± SD period of alcohol use was 20.71 ± 12.04 years, and the alcohol intake was 5.88 ± 1.65 units/d. The AUD group demonstrated elevations in all ECG measures (QTd: 46.56 vs 26.67 ms, QTcd: 54.25 vs 30.88 ms, Pd: 44.69 vs 28.54 ms, all P = .000).
AUD patients with excessive alcohol use had a higher risk of arrhythmia and sudden death compared to the control group. Consideration of ECG and referral to cardiologic examinations would contribute to the follow-up and health of patients with AUD.
确定长期酗酒导致酒精使用障碍（AUD）患者出现严重室性心律失常、心房颤动和猝死时QT离散度（QTd）、校正QT离散度（QTcd）和P波离散度（Pd）值的变化情况，这些患者存在过度饮酒问题。
这项横断面研究纳入了48名根据《精神疾病诊断与统计手册》第5版（DSM-5）标准诊断为AUD的个体。排除有精神疾病病史的患者。对照组由48名无精神疾病诊断且不酗酒或滥用其他物质的个体组成。排除体重指数>24.9 kg/m²的参与者。所有参与者均进行了12导联心电图（ECG）检查。
AUD组的平均年龄±标准差为44.35±10.24岁，对照组为40.90±13.45岁。两组在年龄方面无显著差异（P = 0.108）。两组在吸烟状况方面存在显著差异（P = 0.000）。平均饮酒时长±标准差为20.71±12.04年，酒精摄入量为5.88±1.65单位/天。AUD组所有心电图指标均升高（QTd：46.56对26.67 ms，QTcd：54.25对30.88 ms，Pd：44.69对28.54 ms，所有P = 0.000）。
与对照组相比，过度饮酒的AUD患者发生心律失常和猝死的风险更高。考虑进行心电图检查并转诊至心脏科进行检查将有助于AUD患者的随访和健康管理。
