Ural Federal University, Yekaterinburg, Russian Federation.
Ural Federal University, Yekaterinburg, Russian Federation.
Comput Methods Programs Biomed. 2020 Jul;190:105377. doi: 10.1016/j.cmpb.2020.105377. Epub 2020 Jan 31.
The influence of biophysical parameters on the formation of microwave radiation of the human head is poorly studied. Existing approaches to modeling microwave radiation of the human head have limitations associated with simplifying the geometry of human anatomy. The article proposes methodological solutions for numerical modeling of microwave radiation of the brain biological tissues using the geometry obtained from MRI data.
The geometrical characteristics of biological tissues in model are determined using an MRI image of the head. The methodology proposed in the article allows simulation of a human body voxel models performed the Pennes bio-heat transfer equation using the Fenix software package.
Modeling evaluations have shown that anatomical tissues heterogeneities on the surface of the head form temperature gradient of up to 2.0 K, and changes of the microwave radiation up to 0.3 K.
Verification data made by IR thermograph practically coincide with the results of numerical modeling. The fluctuations of the brain microwave radiation are not only the result of thermal processes in its tissues, but are determined by the dynamics of its thermoregulation processes and are an indicator of changes in the physiological processes occurring in it.
生物物理参数对人头颅微波辐射形成的影响尚未得到充分研究。现有的人头颅微波辐射建模方法存在与简化人体解剖结构相关的局限性。本文提出了使用从 MRI 数据中获得的几何形状对脑组织微波辐射进行数值建模的方法学解决方案。
模型中的生物组织的几何特征是通过头部 MRI 图像确定的。本文提出的方法允许使用 Fenix 软件包模拟人体体素模型，同时执行 Pennes 生物传热方程。
建模评估表明，头部表面的解剖组织不均匀性会形成高达 2.0 K 的温度梯度，以及高达 0.3 K 的微波辐射变化。
IR 热像仪的验证数据与数值建模结果基本一致。大脑微波辐射的波动不仅是其组织中热过程的结果，还取决于其体温调节过程的动态，并且是发生在其中的生理过程变化的指标。
