Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Biogerontology. 2020 Jun;21(3):275-291. doi: 10.1007/s10522-020-09862-2. Epub 2020 Feb 18.
Ageing is a multifactorial and integrated gradual deterioration affecting the most of biological process of cells. MiRNAs are differentially expressed in the cellular senescence and play important role in regulating of genes expression involved in features of ageing. The perception of miRNAs functions in ageing regulation can be useful in clarifying the mechanisms underlying ageing and designing of therapeutic strategies. The preservation of genomic integrity through DNA damage response (DDR) is related to the process of cellular senescence. The recent studies have shown that miRNAs has directly regulated the expression of numerous proteins in DDR pathways. In this review study, DDR pathways, miRNA biogenesis and functions, current finding on DDR regulations, molecular biology of ageing and the role of miRNAs in these processes have been studied. Finally, a brief explanation about the therapeutic function of miRNAs in ageing regarding its regulation of DDR has been provided.
衰老是一个多因素的、综合的、渐进的过程，影响着细胞的大多数生物学过程。miRNAs 在细胞衰老过程中表达差异，并在调节与衰老特征相关的基因表达中发挥重要作用。对miRNAs 在衰老调控中的功能的认识可以有助于阐明衰老的机制，并设计治疗策略。通过 DNA 损伤反应 (DDR) 来维持基因组完整性与细胞衰老过程有关。最近的研究表明，miRNAs 可以直接调节 DDR 途径中许多蛋白质的表达。在这项综述研究中，研究了 DDR 途径、miRNA 的生物发生和功能、DDR 调节的最新发现、衰老的分子生物学以及 miRNAs 在这些过程中的作用。最后，简要说明了 miRNA 在衰老中的治疗功能，以及其对 DDR 的调节作用。
