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核医学中的临床前至临床转化治疗学。

Bench-to-Bedside Theranostics in Nuclear Medicine.

机构信息

The Persian Gulf Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy (MIRT), Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.

Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.

出版信息

Curr Pharm Des. 2020;26(31):3804-3811. doi: 10.2174/1381612826666200218104313.

Abstract

The optimum selection of the appropriate radiolabelled probe for the right target and the right patient is the foundation of theranostics in personalised medicine. In nuclear medicine, this process is realised through the appropriate choice of radiopharmaceuticals based on molecular biomarkers regarding molecular imaging. Theranostics is developing a strategy that can be used to implement accepted tools for individual molecular targeting, including diagnostics, and advances in genomic molecular knowledge, which has led to identifying theranostics biomaterials that have the potency to diagnose and treat malignancies. Today, numerous studies have reported on the discovery and execution of these radiotracers in personalised medicine. In this review, we presented our point of view of the most important theranostics agents that can be used to treat several types of malignancies. Molecular targeted radionuclide treatment methods based on theranostics are excellent paradigms of the relationship between molecular imaging and therapy that has been used to provide individualised or personalised patient care. Toward that end, a precise planned prospective examination of theranostics must be done to compare this approach to more standard therapies.

摘要

对于个体化医学中的治疗,最佳选择适当的放射性探针用于正确的靶标和正确的患者是其基础。在核医学中,该过程通过基于分子成像的分子生物标志物的适当选择放射性药物来实现。治疗学正在开发一种策略,可用于实施针对个体分子靶向的公认工具,包括诊断以及基因组分子知识的进步,这导致鉴定出有潜力诊断和治疗恶性肿瘤的治疗学生物材料。如今,许多研究报告了在个体化医学中发现和执行这些放射性示踪剂的情况。在这篇综述中,我们提出了我们对可用于治疗多种类型恶性肿瘤的最重要治疗学试剂的观点。基于治疗学的分子靶向放射性核素治疗方法是分子成像与治疗之间关系的极佳范例,已用于提供个体化或个性化的患者护理。为此,必须进行精确的、有计划的前瞻性治疗学检查,将这种方法与更标准的治疗方法进行比较。

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